K Banhatti Polynomials of Remdesivir, Chloroquine, Hydroxychloroquine: Research Advances for the Prevention and Treatment of COVID-19

International Journal of Applied Chemistry

© 2020 by SSRG - IJAC Journal

Volume 7 Issue 2

Year of Publication : 2020

Authors : V.R.Kulli

10.14445/23939133/IJAC-V7I2P107

How to Cite?

V.R.Kulli, "K Banhatti Polynomials of Remdesivir, Chloroquine, Hydroxychloroquine: Research Advances for the Prevention and Treatment of COVID-19," SSRG International Journal of Applied Chemistry, vol. 7,  no. 2, pp. 48-55, 2020. Crossref, https://doi.org/10.14445/23939133/IJAC-V7I2P107

Abstract:

In this study, we obtain some topological properties of remdesivir, chloroquine, hydroxychloroquine used to inhibit the outbreak of COVID-19. We determine some K Banhatti polynomials for these three chemical structures. In Chemical Science, chemical, biological, pharmaceutical properties of molecular structure are useful for drug design. These properties can be studied by topological index calculation. Considering this, our findings may be useful in obtaining new drug and vaccine for the treatment of COVID-19.

Keywords:

molecular structures, K Banhatti polynomials, remdesivir, chloroquine, hydroxychloroquine.

References:

[1] C.Huang, et al., “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”, The Lancet Vol. 395, 10223, pp. 497-506 2020, doi:10.1016/S0140-6736(20) 30183-5.
[2] J.S. Morse, T Lalonde, S. Xu and M.R. Liu, “Learning from the past: Possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019 nCoV”, Chem. Bio.Chem 21(5) (2020) 730-738. doi:10.10D2/cbic.202000047.
[3] J.Lung, et al. “The potential chemical structure of anti- SARS CoV-2 RNA dependent RNA polymerase”, J. Med. Virol, (2020) 1-5, doi:10-1002/jmv.25761.
[4] D.Wang, B. Hu, C. Hu, “et al Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirusinfected pneumonia in Wuhan, China”, JAMA (2020) doi:10.1001/jama-2020.1585.
[5] M.Wang, et al., Remdesivir and chloroquine “effectively inhabit the recently emerged novel coronavirus (2019- nCoV) in vitro”, Cell Research, Vol. 30, pp. 269-271, 2020. doi:10.1038/s41422-020-0282-0.
[6] E.Schrenzenmeier and T. Dorner, “Mechanisms of action of hydroxychloroquine and chloroquine implications of rheumatology”, Nat. Rev. Rheumatol, Vol. 16 (2020) 155-166.
[7] D.Zhou, S.M. Dai and Q. Tongg, “COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and
progression”, J. Antimicrob. Chemother. 2020:dkaa 114, doi:10.1093/jac.dkaa114.
[8] X.Xu, et al., “Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission”, Sci. China Life Sci. Vol. 63(3). pp. 457-460, 2020 doi:10.1007/s 11427-020-1637-5.
[9] D.Plantone and T. Koudriavtseva, “Current and future use of chloroquine and hydroxychloroquine in infections, immune, Neoplastic and Neurological disease: A Mini-Review”, Clin. Drug Investing, Vol. 38(8), pp. 653-671, 2018 doi: 10.1007/s40261-018-4056-y (PubMed:29737455).
[10] “FDA: Emergency Use Authorization Information (Link)”.
[11] I.Gutman and O.E. Polansky, “Mathematical Concepts in Organic Chemistry”, Springer, Berlin (1986).
[12] V.R.Kulli, B. Chaluvaraju and T.V. Asha, “Multiplicative product connectivity and sum connectivity indices of chemical structures in drugs”, Research Review International Journal of Multidisciplinary, 4(2) (2019) 949-953.
[13] V.R.Kulli, “On K Banhatti indices of graphs”, Journal of Computer and Mathematical Sciences, 7(2016) 213-218.
[14] V.R.Kulli, “On K hyper-Banhatti indices and coindices of graphs”, International Research Journal of Pure Algebra, 6(5) (2016) 300-304.
[15] V.R.Kulli, “New K Banhatti topological indices”, International Journal of Fuzzy Mathematical Archive, 12(1) (2017) 29-37.
[16] V.R.Kulli, B. Chaluvaraju and H.S. Boregowda, “Connectivity Banhatti indices for certain families of benzenoid systems”, Journal of Ultra Chemistry, 13(4) (2017) 81-87.
[17] V.R.Kulli, “Computing Banhatti indices of networks”, International Journal of Advances in Mathematics, 2018(1) 2018) 31-40.
[18] V.R.Kulli, “K Banhatti indices of chloroquine and hydroxychloroquine: Research Applied for the treatment and prevention of COVID-19”, SSRG International Journal of Applied Chemistry, 7(1)(2020) 63-68.
[19] V.R.Kulli, “Revan indices of chloroquine and hydroxychloroquine, remdesivir: Research advances for the treatment of COVID-19”, International Journal of Engineering Sciences and Research Technology, 9(5) (2020) 73-84.
[20] V.R.Kulli, “Revan indices of chloroquine and hydroxychloroquine, remdesivir: Research advances for the treatment of COVID-19”, SSRG International Journal of Applied Chemistry, 7(2) (2020) 6-12.