Ki -67 proliferative index as a predictive tool for axillary pathological complete response in node-positive breast cancer

International Journal of Medical Science

© 2020 by SSRG - IJMS Journal

Volume 7 Issue 11

Year of Publication : 2020

Authors : Abdalla Saad Abdalla Al-Zawi

10.14445/23939117/IJMS-V7I11P101

How to Cite?

Abdalla Saad Abdalla Al-Zawi, "Ki -67 proliferative index as a predictive tool for axillary pathological complete response in node-positive breast cancer," SSRG International Journal of Medical Science, vol. 7,  no. 11, pp. 1-4, 2020. Crossref, https://doi.org/10.14445/23939117/IJMS-V7I11P101

Abstract:

Background: Upfront chemotherapy is considered the standard of care in the management of early breast cancer including node-positive disease.Ki-67 proliferation index is a biomarker that can be used to predict the histopathological response to therapeutic upfront chemotherapy in the breast primary tumor as well as predict the prognosis.
Objective: Our aim in this study, to address the predictive/prognostic value of Ki-67 proliferative index in downgrading the axilla in node-positive breast cancer. Material and Methods: A group of 64 patients included, have been diagnosed with node-positive breast cancer and triaged for neoadjuvant chemotherapy before surgical intervention. The Ki-67 proliferative index has been measured before chemotherapy and the correlation between Ki-67 expression and achievement of pathological complete response has been explored.
Results: The patient's group with high Ki-67 and both breast and axillary p-CR is 08 patients (12.5%), and the group with high Ki-67 and only axillary p-CR is 07 patients (11%), which gives a sum of 15 patients (23.4%) who achieved p-CR.
Conclusion: The outcome of the current study shows that there was a marginally significant correlation between the p-CR (Complete Pathological Response) and higher rates of Ki-67 expression.

Keywords:

Breast cancer, Ki-67, Neoadjuvant chemotherapy, Axillary lymph nodes

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