Histological categorization of stromal desmoplasia in breast cancer and its diagnostic and prognostic utility

International Journal of Medical Science

© 2017 by SSRG - IJMS Journal

Volume 4 Issue 6

Year of Publication : 2017

Authors : Mariam Shadan, Nazoora Khan, Mohammad Amanullah Khan, Hena Ansari and Sufian Zaheer

10.14445/23939117/IJMS-V4I6P102

How to Cite?

Mariam Shadan, Nazoora Khan, Mohammad Amanullah Khan, Hena Ansari and Sufian Zaheer, "Histological categorization of stromal desmoplasia in breast cancer and its diagnostic and prognostic utility," SSRG International Journal of Medical Science, vol. 4,  no. 6, pp. 8-11, 2017. Crossref, https://doi.org/10.14445/23939117/IJMS-V4I6P102

Abstract:

The interplay between a tumor and its environment is exemplified by the morphological changes observed in the stroma of human breast cancer. These changes are evident as stromal desmoplastic reaction. This study evaluated the association of these stromal changes with Tumor size, Tumor grade and axillary node status. Histopathological evaluation showed marked correlation of desmoplastic reaction with higher grade and positive nodes were associated with immature desmoplastic reaction (p<0.05) however no association with tumor size was noted. In conclusion, stromal desmoplastic reaction can be potentially utilized to predict the grade and nodal status of patients. Therefore they can used as prognostic indicators and provide supplementary information regarding known adverse prognostic factors.

Keywords:

Breast cancer, desmoplasia, prognosis, grading.

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