Synthesis and Evaluation of Antimicrobial Activities of New 1,2,4-Triazole Derivatives

International Journal of Applied Chemistry

© 2020 by SSRG - IJAC Journal

Volume 7 Issue 2

Year of Publication : 2020

Authors : Asawari Mokal

10.14445/23939133/IJAC-V7I2P101

How to Cite?

Asawari Mokal, "Synthesis and Evaluation of Antimicrobial Activities of New 1,2,4-Triazole Derivatives," SSRG International Journal of Applied Chemistry, vol. 7,  no. 2, pp. 1-5, 2020. Crossref, https://doi.org/10.14445/23939133/IJAC-V7I2P101

Abstract:

Extensive research is being carried out in medicinal chemistry, on 1,2 ,4- triazoles due to it’s wide pharmacological features. It is the core structure of many natural and synthetic pharmaceuticals. This versatile 1,2,4-triazole moiety can be structurally modified to get newer analogues to overcome the résistance problem. The presented work describes synthesis of a new series of 1,2,4-triazole derivatives namely 3,5-diarylsubstituted-1,2,4-triazole derivatives via benzoxinones. The corresponding 5-substituted salicylamides, required as precursors were prepared as per the literature. The treatment of benzoxinones with hydrazine hydrate afforded the 3,5-diarylsubstituted-1,2,4- triazoles. The structure of each novel compound was confirmed on the basis of 1H NMR spectral data and elemental analysis .Upon being tested for their antimicrobial activity against Gram positive, Gram negative bacteria, and fungi, some of the compounds exhibited moderate inhibitory effects against both Gram positive and negative bacteria and certain strains of fungi.

Keywords:

Antimicrobial activity, Antifungal activity, benzoxinones, 3,5-diarylsubstituted-1,2,4-triazole derivatives, Gram positive and Gram negative bacteria and fungi

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