The Synthesis of Optically-Active erythroMethylphenidate by Diastereoselective Hydrogenation using Ru-BINAP Complex Catalyst –II*

International Journal of Applied Chemistry

© 2024 by SSRG - IJAC Journal

Volume 11 Issue 1

Year of Publication : 2024

Authors : Yoshifumi Yuasa, Akiko Horizoe

10.14445/23939133/IJAC-V11I1P102

How to Cite?

Yoshifumi Yuasa, Akiko Horizoe, "The Synthesis of Optically-Active erythroMethylphenidate by Diastereoselective Hydrogenation using Ru-BINAP Complex Catalyst –II*," SSRG International Journal of Applied Chemistry, vol. 11,  no. 1, pp. 7-11, 2024. Crossref, https://doi.org/10.14445/23939133/IJAC-V11I1P102

Abstract:

Optically-active methyl 2-phenyl-2-(2'-pyperidyl)acetate (Methylphenidate) 1 could be produced from methyl 7-N- (benzyloxycarbonylamino)-3-oxo-2-phenylheptanoate 2 by diastereoselective hydrogenation using the Ru-BINAP complex catalyst as the key step of 3 steps.

Keywords:

(2S, 2R')-2-phenyl-2-(2'-pyperidyl)acetate, methyl (2S, 3R)-7-N-(benzyloxy- carbonylamino)-3-hyroxy-2-phenylheptanoate, diastereoselective hydrogenation, Ru-BINAP complex catalyst.

References:

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