Synthesis of Gelatin Graft Itaconic Drugs

International Journal of Applied Chemistry

© 2019 by SSRG - IJAC Journal

Volume 6 Issue 3

Year of Publication : 2019

Authors : Firyal Mohammed Ali , Wameedh Sameer Sadeq

10.14445/23939133/IJAC-V6I3P103

How to Cite?

Firyal Mohammed Ali , Wameedh Sameer Sadeq, "Synthesis of Gelatin Graft Itaconic Drugs," SSRG International Journal of Applied Chemistry, vol. 6,  no. 3, pp. 13-17, 2019. Crossref, https://doi.org/10.14445/23939133/IJAC-V6I3P103

Abstract:

This work involved preparation new drug adhesive to treatment the wounds and inflammations, as bio adhesive , which have high viscosity and treatment the wounds by the adhesion of the wound when it put as well as the rapidity treatment of external inflammation, because it remains inherent to the position of injury fast time,. A new bio adhesive polymer was prepared by
modification of Gelatin structure with Itoconic acid as a insertion by using cericion it , was substituted with amino drugs produced amide polymer. This design carries controlled delivery which could release the entrapped drug over an extended period of time due to its biodegradable, nontoxic and slow digesting nature. The prepared adhesive drug polymer was characterized by FTIR, 1H-NMR spectroscopes, thermo gravimetric analysis TGA and DSC were considered. Physical properties of prepared polymer was measured, Biological activity was studied for adhesive drug polymer, this new adhesive drug biological polymers were applied on different infected mice and wounds, It gave outstanding results and compliance mice infected with a full recovery by a short period of time. The prepared drug copolymer was analyzed in different pH values at 37 0C in vitro study and controlled drug release was compared at zero time and after three days .The rate of hydrolysis in basic medium was found higher than acidic medium. It was concluded that modified drug release with extended drug action via slow release and in vivo performance was noted to be promising.

Keywords:

Gelatin , controlled delivery, adhesive drug polymers , Graft Copolymer

References:

[1] Susheel K., Sabaa M.W., “Polysaccharide Based Graft Copolymers”, 1Bahra University, India, 2Faculty of Science Cairo University, Egypt, 2013.
[2] Vijay K. Thakur and Manju K. Thakur, “Handbook of Polymers for Pharmaceutical Technologies”, Volume 2, Washington State University, USA, 2015.
[3] Rohini, Neeraj A., Anupam J., and Alok M., “Polymeric Prodrugs: Recent Achievements and General Strategies”, J Antivir Antiretrovir S15.p.p 1-12, 2013.
[4] Zhang Y., Chan H.F., and Leong K.W., “Advanced materials and processing for drug delivery: the past and the future, Advanced drug”, delivery reviews, 65 p.p 104-120, 2013.
[5] Lehár J., Krueger A.S., Avery W., Heilbut A.M., Johansen L.M., Price E.R., Rickles R.J., Short Iii G.F., Staunton J.E., Jin X., “Synergistic drug combinations tend to improve therapeutically relevant selectivity”, Nature biotechnology, 27, 659-666, 2009.
[6] Wan-Wan Y. and Erik P.f, “Reservoir-Based Polymer Drug Delivery Systems”, Journal of Laboratory Automation, 17(1) 50–58, 2012.
[7] Ndidi C. Ngwuluka, Nelson A. Ochekpe and Okezie I. Aruoma, “Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery”, polymers, 6, 1312-1332, 2014.
[8] Ololade O., “Natural Polymers Industry Techniques and Applications”, University of Lagos, Nigeria, Springer International Publishing Switzerland, p 63, 2016.
[9] Ridley, B.L., M.A. O'Neill, and D. Mohnen, Gelatin:structure, biosynthesis, and oligogalacturonide-related signaling. Phytochemistry, 2001. 57(6): p. 929-67.
[10] Fischer, R.L. and A.B. Bennett, Role of Cell Wall Hydrolases in Fruit Ripening. Annual Review of Plant Physiology and Plant Molecular Biology, 1991. 42: p. 675-703.
[11] Mort, A.J., F. Qiu, and N.O. Maness, Determination of the pattern of methyl esterification in Gelatin. Distribution of contiguous nonesterified residues. Carbohydr Res, 1993. 247:p. 21-35.
[12] Ralet, M.C., et al., Mapping sugar beet Gelatin acetylation pattern. Phytochemistry, 2005. 66(15): p. 1832-43.
[13] Levigne, S., M.C. Ralet, and J.F. Thibault, Characterisation of Gelatins extracted from fresh sugar beet under different conditions using an experimental design. Carbohydr Polymers, 2002. 49(2).
[14] Rolin, C., Commercial Gelatin Preparations, in Gelatin and Their Manipulation, G.B. Seymour and J.P. Knox, Editors.2002. p. 222-239.
[15] Rahul V. M., Olobayo O. K., Martins O. E., Bill K., (Physical, thermal and sorption profile of starch obtained from tacca leontopetaloides), Starch - Stärke, 57 (2):55-61, (2005).
[16] Dumitiu S. (Polysaccharides-structural diversity and functional versatility), 2nd ed ,Library of Congress, New York, (2005).
[17] Roper H., (Applications of starch and its derivatives), Carbohydr Eur. 15: 14-21, (1996).
[18] Vilivalam V.D., Illum L., Iqbal K., (Starch capsules: an alternative system for oral drug delivery), Pharm. Sci.Technol. Today, 3(2): 64- 69, (2000).
[19] Milojevic S., Newton J.M., Cummings J.H., Gibson G.R., Botham R.L., Ring S.G.,Stockham M.,Allwood M.C. ,(Amylose as a coating for drug delivery to the colon: preparation and in vitro evaluation using 5-aminosalicylic acid pellets), J. Control. Release. 38:75-84, (1996).
[20] Désévaux C., Dubreuil P., Lenaerts V., Girard C., (Tissue reaction and biodegradation of implanted cross-linked high amylose starch in rats), J. Biomed. Mater. Res. 63(6): 772-779, (2002).
[21] Mulhbacher J., Ispas-SzaboP., Lenaerts V., Mateescu M.A., (Cross-linked high amylose starch derivatives as matrices for controlled release of high drug loadings), J. Control. Rel, 76: 51-58, (2001).
[22] Nabais T.,Brouillet F., Kyriacos S., Mroueh M., Amores da Silva P.,Bataille B., Chebli C., Cartilier L.,( High-amylose carboxymethyl starch matrices for oral sustained drug-release: in vitro and in vivo evaluation), Eur. J. Pharm. Biopharm, 65: 371-378,(2007).
[23] Teramoto N., Motoyama T., Yosomiya R.,Shibata M. ,(Synthesis, thermal properties, and biodegradability of propyletherified starch,) Eur. Polym. J., 39:255-261, (2003).
[24] Araújo M.A., Cunha A., Mota M., (Enzymatic degradation of starch-based thermoplastic compounds used in protheses: identification of the degradation products in solution,) Biomaterials, 25(13):2687-2693, (2004).
[25] Zhang J.F., Sun X.Z., (Mechanical properties of PLA/starch composites compatibilized by itoconic acd), Biomacromolecules, 5(4): 1446-1451, (2004).
[26] Pareta R., Edirisinghe M.J., (A novel method for the preparation of starch films and coatings), Carbohydr. Polym, 63: 425-431, (2006).
[27] Burr R.C., Fanta G.F., Doane W.M., Russell C.R., (Graft copolymers of starch and mixtures of acrylamide and acrylic acid), Journal of Applied Polymer Science, 20: 3201-3204,(1976).
[28] Wang Z., Liu Z., (The optimization of synthesizing graft copolymer of starch with vinyl monomers), J. Wuhan Univ. Technol., 21(2): 83-87, (2006). 29-Athawale V.D., Lele V., (Graft copolymerization onto starch. II. Grafting of acrylic acid and preparation of it's hydrogels), Carbohydr. Polym.,
35(7): 21-27,(1998).
[29] Trimnell D., Stout E.I., (Grafting acrylic acid onto starch and poly (vinyl alcohol) by photolysis), J. Appl. Polym. Sci., 25(10): 2431- 2434, (1980).
[30] 30-Park, I.H., Song, S.Y., Song, B.K., (Gratf polymerization of acrylic acid onto corn starch in aqueous isopropanol solution), Macro. Mat. Eng., 267(1): 20-26, (1999).
[31] Mohammad S., (Synthesis of starch-g-poly (acrylic acid-co-2- hydroxy ethyl methacrylate) as a potential pH-sensitive hydrogel- based drug delivery system), Turk J Chem, 35: 723 -733, (2011).
[32] Deepak P., Reena S., (Synthesis and characterization of graft copolymers of methacrylic acid onto gelatinized potato starch using chromic acid initiator in presence of air),Adv. Mat. Let. , 3(2): 136- 142,(2012).
[33] P.Armitage(2005)Statistical methods in medical researchin blank well scientific Publication,USA(1971)Claremunt,M,A.Garcia,ConceptionLap
ez and Jose Elguero,ARKIVOC (vii),91.