A highly sensitive electrochemical determination of Isoniazid in pharmaceutical preparation by differential pulse Polarography

International Journal of Chemical Engineering Research

© 2016 by SSRG - IJCER Journal

Volume 3 Issue 2

Year of Publication : 2016

Authors : Salam Abbas Hassan AL-Ameri, Mohammed D. Majeed AL-Mayahi

10.14445/23945370/IJCER-V3I5P102

How to Cite?

Salam Abbas Hassan AL-Ameri, Mohammed D. Majeed AL-Mayahi, "A highly sensitive electrochemical determination of Isoniazid in pharmaceutical preparation by differential pulse Polarography," SSRG International Journal of Chemical Engineering Research, vol. 3,  no. 2, pp. 9-15, 2016. Crossref, https://doi.org/10.14445/23945370/IJCER-V3I5P102

Abstract:

A simple strategy and highly sensitive electrochemical method was developed and described in Britton _ Robinson buffer for isoniazid determination by Differential Pulse Polarography (DPP). A dropping mercury electrode (DME) was used to characterize the performance of the sensor. The reduction process on the (DME) gave a rise with one peak over Ep-1.17 v (vs. Ag/AgCl/), within the studied pH range (2 – 9), 3M KNO3 as a supporting electrolyte and 4mm3 mercury drop size at 25°C. A standard calibration plot was conducted in the range between 0.05- 0.40μg.ml-1. The monitored differential pulse current was directly proportional to the concentration of Isoniazid and it showed a linear response in the studied range (correlation coefficient (r) = 0.9997) and the detection limit was 0.05μg. ml-1. This method effectively applied in commercial Isoniazid pharmaceuticals.

Keywords:

Isoniazid, pharmaceutical preparation, Differential pulse polarography.

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