MEMS-Based Biosensors for Mass Detection in Single Cells-Review of Techniques and Approaches

International Journal of Electronics and Communication Engineering

© 2024 by SSRG - IJECE Journal

Volume 11 Issue 8

Year of Publication : 2024

Authors : A.L.G.N. Aditya, Elizabeth Rufus

10.14445/23488549/IJECE-V11I8P130

How to Cite?

A.L.G.N. Aditya, Elizabeth Rufus, "MEMS-Based Biosensors for Mass Detection in Single Cells-Review of Techniques and Approaches," SSRG International Journal of Electronics and Communication Engineering, vol. 11,  no. 8, pp. 312-324, 2024. Crossref, https://doi.org/10.14445/23488549/IJECE-V11I8P130

Abstract:

The significance of early detection and diagnosis in medicine is widely acknowledged, whereas clinicopathological methods, which are more effective after diseases have progressed, tend to receive less attention. With hematological diseases, the chances of cure or extension of life span are higher with early-onset diagnosis. Early detection of the disease onset and progression is vital and challenging for reasons of minuscule changes in molecular or cellular behaviors. Cells are the basic building block, so understanding the changes at the cellular level is crucial to estimating the ecological and biogeochemical models. In the case of single-cell studies, sensitivity and resolution are the key challenges that the scientific community addresses as the key focus areas. With traditional label-free sensing techniques, though these challenges are addressed, the sample preparation, handling, and characterization are setbacks for making their gold standards. With emerging technologies incidental to micro/nanofabrication processes, MEMS-based resonant sensors emerged as a paradigm technique for the detection of biophysical changes in a single-cell study due to their good sensitivity and resolution. This paper focuses on the review of techniques and methods to detect the mass of biological cells and compares their results with the MEMS Resonating mass sensors. It also focuses on the technique of resonant frequency shift and approaches for improving the sensitivity of the resonators by focusing on reported structures.

Keywords:

Cell behaviour studies, Label-free sensing, Micro/nano-fabrication, Micro-electro mechanical system, Resonant sensors.

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