Improving Sickle Cell Anaemia Classification in Nilgiri Tribes through Multimodal RBC Spot Extraction Using Optimized Deep Stacking Network Algorithm

International Journal of Electronics and Communication Engineering |
© 2025 by SSRG - IJECE Journal |
Volume 12 Issue 2 |
Year of Publication : 2025 |
Authors : Maria Sheeba, K. Sarojini |
How to Cite?
Maria Sheeba, K. Sarojini, "Improving Sickle Cell Anaemia Classification in Nilgiri Tribes through Multimodal RBC Spot Extraction Using Optimized Deep Stacking Network Algorithm," SSRG International Journal of Electronics and Communication Engineering, vol. 12, no. 2, pp. 107-119, 2025. Crossref, https://doi.org/10.14445/23488549/IJECE-V12I2P110
Abstract:
Sickle Cell Anemia (SCA) is a prevalent genetic blood disorder that disproportionately affects the health of the Nilgiri tribes. Early and accurate diagnosis is pivotal for effective management of the disease. This research proposes an innovative approach to Multimodal RBC Spot Extraction using Optimized Deep Stacking Network (MRSE-ODSN) Algorithm to classify SCA diagnosis within this community by harnessing the synergies of multimodal Red Blood Cell (RBC) image analysis. The MRSE-ODSN framework begins with acquiring diverse RBC images encompassing brightfield microscopy, phase-contrast imaging, and fluorescence microscopy. Each imaging modality captures distinctive aspects of RBC morphology and function. The sample data were collected from the NAWA-Nilgiri Adivasi Welfare Association in Nilgris, which contains data from 300 patients with 14 features related to SCA that were acquired. Rigorous preprocessing and augmentation techniques ensure data quality and resilience. A sophisticated architecture tailored for sequential feature extraction from multimodal RBC images. ODSN expertly integrates with CNN to classify sickle cell anemia efficiently within the Nilgiri tribes. The proposed model obtained 98.01 percent accuracy. By employing MRSE-ODSN, healthcare practitioners can potentially offer timely interventions, personalized treatments, and enhanced disease management strategies, thereby positively impacting the health and well-being of the Nilgiri tribes.
Keywords:
Sickle Cell Anemia, Classification, Red Blood Cell, Multimodal RBC Spot Extraction, Optimized Deep Stacking Network, Convolution Neural Network, Nilgiri tribes.
References:
[1] Kelly E. Jones et al., “Executive Functioning Predicts Adaptive Functioning and Self-Care Independence in Pediatric Sickle Cell Disease,” Journal of Pediatric Psychology, vol. 47, no. 2, pp. 206-214, 2021.
[CrossRef] [Google Scholar] [Publisher Link]
[2] Michele Arigliani et al., “Lung Clearance Index May Detect Early Peripheral Lung Disease in Sickle Cell Anemia,” Annals of the American Thoracic Society, vol. 19, no. 9, pp. 1507-1515, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[3] Julie Kanter et al., “Biologic and Clinical Efficacy of LentiGlobin for Sickle Cell Disease,” New England Journal of Medicine, vol. 386, no. 7, pp. 617-628, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[4] Suzanne Verlhac et al., “Evolution of Extracranial Internal Carotid Artery Disease in Children with Sickle Cell Anemia,” Stroke, vol. 53, no. 8, pp. 2637-2646, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[5] Belhu Metaferia et al., “Phenotypic Screening of the ReFRAME Drug Repurposing Library to Discover New Drugs for Treating Sickle Cell Disease,” Proceedings of the National Academy of Sciences, vol. 119, no. 40, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[6] William A. Eaton, “Impact of Hemoglobin Biophysical Studies on Molecular Pathogenesis and Drug Therapy for Sickle Cell Disease,” Molecular Aspects of Medicine, vol. 84, pp. 1-10, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[7] Jennifer M. Knight-Madden, and Ian R. Hambleton, “Inhaled Bronchodilators for Acute Chest Syndrome in People with Sickle Cell Disease,” Cochrane Database of Systematic Reviews, vol. 12, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[8] David C. Rees et al., “A Randomized, Placebo-Controlled, Double-Blind Trial of Canakinumab in Children and Young Adults with Sickle Cell Anemia,” Blood, The Journal of the American Society of Hematology, vol. 139, no. 17, pp. 2642-2652, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[9] Rahyssa Rodrigues Sales et al., “Fetal Hemoglobin-Boosting Haplotypes of BCL11A Gene and HBS1L-MYB Intergenic Region in the Prediction of Clinical and Hematological Outcomes in a Cohort of Children with Sickle Cell Anemia,” Journal of Human Genetics, vol. 67, pp. 701-709, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[10] Andrew M. Heitzer et al., “Neurocognitive Functioning in Preschool Children with Sickle Cell Disease,” Pediatric Blood & Cancer, vol. 69, no. 3, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[11] Mabirizi Vicent, Kawuma Simon, and Safari Yonasi, “An Algorithm to Detect Overlapping Red Blood Cells for Sickle Cell Disease Diagnosis,” IET Image Processing, vol. 16, no. 6, pp. 1669-1677, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[12] Emmanuel Gbenga Dada, David Opeoluwa Oyewola, and Stephen Bassi Joseph, “Deep Convolutional Neural Network Model for Detection of Sickle Cell Anemia in Peripheral Blood Images,” Communication in Physical Sciences, vol. 8, no. 1, pp. 9-22, 2022.
[Google Scholar] [Publisher Link]
[13] Fareen Farzana Wahed et al., “Detection of Sickle Cell Anemia using SVM Classifier,” AIP Conference Proceedings, vol. 2405, no. 1, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[14] Amina Nardo-Marino et al., “Automating Pitted Red Blood Cell Counts using Deep Neural Network Analysis: A New Method for Measuring Splenic Function in Sickle Cell Anaemia,” Frontiers in Physiology, vol. 13, pp. 1-11, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[15] Peter M. Douglass, Timothy O’Connor, and Bahram Javidi, “Automated Sickle Cell Disease Identification in Human Red Blood Cells using a Lensless Single Random Phase Encoding Biosensor and Convolutional Neural Networks,” Optics Express, vol. 30, no. 20, pp. 35965-35977, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[16] Mohammed Gollapalli, and Aljawharah Alfaleh, “An Artificial Intelligence Approach for Data Modelling Patients Inheritance of Sickle Cell Disease (SCD) in the Eastern Regions of Saudi Arabia,” Mathematical Modelling of Engineering Problems, vol. 9, no. 4, pp. 1079-1088, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[17] Marya Butt, and Ander de Keijzer, “Using Transfer Learning to Train a Binary Classifier for Lorrca Ektacytometery Microscopic Images of Sickle Cells and Healthy Red Blood Cells,” Data, vol. 7, no. 9, pp. 1-21, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[18] Maxime Darrin et al., “Classification of Red Cell Dynamics with Convolutional and Recurrent Neural Networks: A Sickle Cell Disease Case Study,” Scientific Reports, vol. 13, pp. 1-12, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[19] S. Alagu, Kavitha Ganesan, and K. Bhoopathy Bagan, “A Novel Deep Learning Approach for Sickle Cell Anemia Detection in Human RBCs using an Improved Wrapper-based Feature Selection Technique in Microscopic Blood Smear Images,” Biomedical Engineering/Biomedizinische Technik, vol. 68, no. 2, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[20] Samiksha Soni, Hardik Thakkar, and Bikesh Kumar Singh, “Transfer Learning for Sickle Cell Anemia and Trait Classification,” Second International Conference on Power, Control and Computing Technologies, Raipur, India, pp. 1-5, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[21] Mohammed Gollapalli et al., “Text Mining on Hospital Stay Durations and Management of Sickle Cell Disease Patients,” 14th International Conference on Computational Intelligence and Communication Networks, Al-Khobar, Saudi Arabia, pp. 1-6, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[22] Shaurjya Mandal, Debanjan Das, and Venkanna Udutalapally, “mSickle: Sickle Cell Identification through Gradient Evaluation and Smartphone Microscopy,” Journal of Ambient Intelligence and Humanized Computing, vol. 14, pp. 13319-13331, 2023.[CrossRef] [Google Scholar] [Publisher Link]