Dilemma in the Cytodiagnosis of Sarcomatoid Variant of Anaplastic Carcinoma Thyroid-a Case Report
| International Journal of Medical Science |
| © 2018 by SSRG - IJMS Journal |
| Volume 5 Issue 8 |
| Year of Publication : 2018 |
| Authors : Dr Sonali Datar, Dr Rasika Gadkari and Dr Pradip Umap |
10.14445/23939117/IJMS-V5I8P101
How to Cite?
Dr Sonali Datar, Dr Rasika Gadkari and Dr Pradip Umap, "Dilemma in the Cytodiagnosis of Sarcomatoid Variant of Anaplastic Carcinoma Thyroid-a Case Report," SSRG International Journal of Medical Science, vol. 5, no. 8, pp. 1-3, 2018. Crossref, https://doi.org/10.14445/23939117/IJMS-V5I8P101
Abstract:
Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. Although less than 5% of thyroid cancers, it is responsible for more than half of deaths attributed to thyroid cancer, with a mortality rate over 90% and a mean survival of six months. The diagnosis of ATC is usually based on clinical examination, cytology, histology, imaging study and immunohistochemistry. FNAC is reported to be 90% accurate in diagnosing ATC. A preoperative cytological diagnosis helps to determine the treatment plan in these patients. ATC needs to be differentiated from high grade tumors with the microscopic features originating from adjacent structures and at times immunohistochemistry is essential for establishing the correct diagnosis. The problems in sarcomatoid variant of ATC are compounded when cellularity is low and epithelial cells are sparse. In such cases diagnosis of malignancy and differentiation from other soft tissue tumors presents major dilemma.
Keywords:
Anaplastic thyroid carcinoma, cytological diagnosis, immunohistochemistry.
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