Molecular Characterization of Type 2 Diabetes Mellitus by Single Nucleotide Polymorphism of Transcription Factor 7 Like 2 Gene

International Journal of Medical Science

© 2018 by SSRG - IJMS Journal

Volume 5 Issue 9

Year of Publication : 2018

Authors : Alaa KH.Mashni, Dr.Tamer Issawi and Dr.Muhammad Farraj

10.14445/23939117/IJMS-V5I9P101

How to Cite?

Alaa KH.Mashni, Dr.Tamer Issawi and Dr.Muhammad Farraj, "Molecular Characterization of Type 2 Diabetes Mellitus by Single Nucleotide Polymorphism of Transcription Factor 7 Like 2 Gene," SSRG International Journal of Medical Science, vol. 5,  no. 9, pp. 1-9, 2018. Crossref, https://doi.org/10.14445/23939117/IJMS-V5I9P101

Abstract:

Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a strong genetic component interacting with environmental factors. Many genes have been significantly associated with developing type 2 diabetes mellitus. Most of these genes have been linked to beta-cell dysfunction, impaired glucose homeostasis and insulin secretion. Transcription factor-7–like 2 (TCF7L2) gene has been found as an unexpected suspect for type 2 diabetes. The strongest and most commonly associated alleles of the TCF7L2 gene in T2DM in many countries are rs7903146 and rs12255372.

Keywords:

   T2DM, TCF7L2, Nucleotide

References:

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