Emerging Multi Drug Resistant Bacterial Strain In Neonatal Intensive Care Unit In A Developing Country-Bangladesh

International Journal of Medical Science

© 2019 by SSRG - IJMS Journal

Volume 6 Issue 8

Year of Publication : 2019

Authors : Aftab Yousuf Raj, Farzana Ahmed

10.14445/23939117/IJMS-V6I8P103

How to Cite?

Aftab Yousuf Raj, Farzana Ahmed, "Emerging Multi Drug Resistant Bacterial Strain In Neonatal Intensive Care Unit In A Developing Country-Bangladesh," SSRG International Journal of Medical Science, vol. 6,  no. 8, pp. 17-22, 2019. Crossref, https://doi.org/10.14445/23939117/IJMS-V6I8P103

Abstract:

Neonatal sepsis is one of the major causes for mortality and morbidity among newborn. Bacterial pathogens and antibiotic sensitivity patterns are different in hospitals of each country. The objective of the present study was to identify the spectrum of bacterial isolates causing septicemia in neonates and to determine their antimicrobial sensitivity pattern. Out of 171 babies with positive septic screening, 82 were culture positive samples, gram positive and gram negative organisms were 28 % and 72 % respectively. Acinetobacter remained the predominant isolate (n=25,30.5%) followed by Coagulase negative Staphylococcus(N=16, 19.5%). Most of the gram positive isolates exhibited higher resistance to penicillin, cephalosporin, macrolides, gentamycin in aminoglycosides group and quinolones. Gram-positive isolates had sensitivity of 100% to chloramphenicol, vancomycin, linezolid followed by rifampicin 84%. In comparison to other antibiotics, sensitivity to these four medicines was significant statistically (P < 0.05). On the other hand, most of the gram negative organisms showed resistance to aminoglycosides and cephalosporin; about two third showed resistant to meropenum, quinolones and zosyn. Best overall sensitivity among Gram-negative isolates was to Polymixin B (100%) and Minocycline (97%), followed by Colistin (83%) which was also significant statistically (P < 0.05). Our study highlights the higher resistance towards commonly used antimicrobials and necessity for periodic survey of etiological agents and their antibiotic susceptibility patterns for the timely alarm of such type of problems.

Keywords:

Antimicrobial resistance, antibiotics, neonatal septicemia.

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