Using Prostatic Fluid Levels of Zinc to Iron Concentration Ratio in Non-Invasive and Highly Accurate Screening for Prostate Cancer

International Journal of Medical Science

© 2019 by SSRG - IJMS Journal

Volume 6 Issue 11

Year of Publication : 2019

Authors : Vladimir Zaichick, Sofia Zaichick

10.14445/23939117/IJMS-V6I11P108

How to Cite?

Vladimir Zaichick, Sofia Zaichick, "Using Prostatic Fluid Levels of Zinc to Iron Concentration Ratio in Non-Invasive and Highly Accurate Screening for Prostate Cancer," SSRG International Journal of Medical Science, vol. 6,  no. 11, pp. 24-31, 2019. Crossref, https://doi.org/10.14445/23939117/IJMS-V6I11P108

Abstract:

Prostate specific antigen (PSA) does not provide the high reliability and precision that is required for an accurate screening for prostate cancer (PCa). The aim of our study was to search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the screening for PCa. For this purpose the levels of Fe and Zn were prospectively evaluated in expressed prostatic fluid (EPF). AlsoZn/Fe concentration ratio was calculated for EPFsamples, obtained from 38 apparently healthy males and from 33, 51, and 24 patients with chronic prostatitis (CP), benign prostatic hyperplasia (BPH) and PCa, respectively. Measurements were performed using an application of energy dispersive X-ray fluorescent (EDXRF) microanalysis developed by us. It was found that in the EPF of cancerous prostatesthe levels of Zn and Zn/Fe were significantly lower in comparison with those in the EPF of normal, inflamed, and hyperplastic prostates. It was shown that “Sensitivity”, “Specificity” and “Accuracy” of PCa identification using the Zn and Zn/Fe levels in the EPF samples were all significantly higher than those resulting from of PSA tests in blood serum. It was concluded that the Zn and Zn/Fe levels in EPF, obtained by EDXRF, is afast, reliable, and noninvasive diagnostic tool that can be successfully used by local, non-urologist physicians at the point-ofcare to provide a highly effective PCa screening and as an additional confirmatory test before a prostate gland biopsy.

Keywords:

Urology screening, Prostate cancer, Benign prostatic hyperplasia, Chronic prostatitis, Expressed Prostatic Fluid, Trace element content, Trace element concentration ratio, Energy-dispersive X-ray fluorescent analysis.

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