The Role of Bisphosphonates In The Management of Bone Metastasis

International Journal of Medical Science

© 2020 by SSRG - IJMS Journal

Volume 7 Issue 10

Year of Publication : 2020

Authors : Ngwobia Peter Agwu, Ahmed Mohammed Umar

10.14445/23939117/IJMS-V7I10P102

How to Cite?

Ngwobia Peter Agwu, Ahmed Mohammed Umar, "The Role of Bisphosphonates In The Management of Bone Metastasis," SSRG International Journal of Medical Science, vol. 7,  no. 10, pp. 5-11, 2020. Crossref, https://doi.org/10.14445/23939117/IJMS-V7I10P102

Abstract:

Metastasis to the bone indicates late and mostly incurable stage of cancer with an associated reduction in the quality of life of the subjects. Bone is a frequent site for distant metastasis, most especially from cancers of the prostate, breast, thyroid, and kidneys. It is associated with increased morbidity resulting from bone pain, spinal cord compression, and pathological fracture. Bisphosphonates are stable analogs of pyrophosphates, and they have been shown to effectively inhibit bone resorption, thereby improving mineral bone density and minimizing the risk of pathological fracture and other skeletal-related events while providing relief of pain in patients with bone metastasis and patients with prostate cancer on androgen deprivation therapy. There are better pain control and less requirement of analgesics in patients treated with bisphosphonates. Severe toxicity to bisphosphonates is uncommon but can arise with osteonecrosis of the jaw been one of the most serious complications. In this article, we review the Mechanism of bone metastasis, the pharmacology and Mechanism of action of bisphosphonates, and their role in the management of patients with bone metastasis supporting it with clinical studies that support their efficacy. We finally review the literature for their possible toxicity

Keywords:

Bisphosphonates, breast cancer, osteonecrosis of the jaw, prostate cancer.

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