The Prognostic value of Hyponatremia and Hypokalemia in Myocardial Infarction Patients

International Journal of Medical Science

© 2020 by SSRG - IJMS Journal

Volume 7 Issue 12

Year of Publication : 2020

Authors : Ahmad Alabrass

10.14445/23939117/IJMS-V7I12P101

How to Cite?

Ahmad Alabrass, "The Prognostic value of Hyponatremia and Hypokalemia in Myocardial Infarction Patients," SSRG International Journal of Medical Science, vol. 7,  no. 12, pp. 1-4, 2020. Crossref, https://doi.org/10.14445/23939117/IJMS-V7I12P101

Abstract:

Syria is one of the countries with a high risk of ischemic heart disease. It is one of the most causes of morbidity and mortality worldwide. Myocardial infarction does not mean simply occlusion of an epicardial artery. Rather, it is a systemic, metabolic, and neurohormonal process that affects and is affected by other systems, including blood ions. In this research, we will study the changes in sodium and potassium in patients with myocardial infarction and their impact on prognosis. This study included 100 patients. Patients were divided into two groups, a high-risk group and a low-risk group based on the GRACE score, and successive laboratory tests were made for both sodium and potassium from admission to discharge. We found the incidence of hyponatremia was 54% and hypokalemia was 64%. We found that early hyponatremia was associated with short-term prognosis (p-value = 0.001), and hyponatremia at discharge was associated with long-term prognosis (p-value = 0.003). We found that early hypokalemia was associated with short-term prognosis (p-value = 0.001). We found a significant association between the development of cardiac shock and hyponatremia (p-value = 0.001, OR = 40.1), and significant association between the development of arrhythmias and hypokalemia (p-value = 0.002, OR = 41.9). We also found that the return of values to normal ranges at discharge indicates improvement and response to treatment.

Keywords:

Myocardial infarction, hyponatremia, hypokalemia.

References:

[1] Aghaeishahsavari M, Noroozianavval M, Veisi P, Parizad R, Samadikhah J. Cardiovascular disease risk factors in patients with confirmed cardiovascular disease. Saudi Med J (2006) 27:1358–61.
[2] Jeldsen KK. Hypokalemia and sudden cardiac death. Exp Clin Cardiol 15(4) (2010) 96-99.
[3] Lobo DN. Fluid, electrolytes, and nutrition. Physiological and Clinical Aspects. Proc Nutr Soc 63(3) (2004) 453-466.
[4] Mati E, Krishnamurthy N, Ashakiran S, Sumathi ME, Prasad R. Dyselectrolytemia in acute myocardial infarction-a retrospective study. J Clin Biomed Sci:2(4) (2012)167-174.
[5] Lim W, Qushmaq, Cook DJ, et al. Elevated Troponin & Myocardial infarction in the intensive care unit: a prospective study. Crit Care;9: (2005) 636-644.
[6] Mudaraddi R, Kulkarni SP, Trivedi DJ, Patil VS, Kamble S. Association of Serum Electrolytes and Urea Levels with Cardiac Markers in Acute Myocardial Infarction. Int J Clin Biochem Res 2015;2(4):233-235.
[7] Mandole MB, Howale DS, Mamatha MT, Sharma D, Gamit D, Pandit DP. Evaluation of renal function tests and serum electrolytes in patients with acute myocardial infarction. Int J Biomed Res 7(9) (2016) 676-679.
[8] Tang Q, Hua Q. Relationship between hyponatremia and in-hospital outcomes in Chinese patients with ST-elevation myocardial infarction. Intern Med 50 (2011) 969-974.
[9] Verma S, Agarwal YB, Sharma SK, Doifode DV. Dyselectrolytaemia in acute myocardial infarction. JIACM 16(3-4) (2015) 201-3.
[10] Shlomai G, Berkovitch A, Pinchevski-Kadir S, Bornstein G, Leibowitz A, Goldenberg I, et al. The association between normal-range admission potassium levels in Israeli patients with acute coronary syndrome and early and late outcomes. Medicine 95(23) (2016) e3778.