Correlation between Prostate Specific Antigen and Acid Phosphatase with Histopathological Findings in Various Prostatic Pathologies
| International Journal of Medical Science |
| © 2015 by SSRG - IJMS Journal |
| Volume 2 Issue 6 |
| Year of Publication : 2015 |
| Authors : Dr Anusha A.M , Dr S.Ranjith and Dr P.T Annamala |
10.14445/23939117/IJMS-V2I6P101
How to Cite?
Dr Anusha A.M , Dr S.Ranjith and Dr P.T Annamala, "Correlation between Prostate Specific Antigen and Acid Phosphatase with Histopathological Findings in Various Prostatic Pathologies," SSRG International Journal of Medical Science, vol. 2, no. 6, pp. 1-6, 2015. Crossref, https://doi.org/10.14445/23939117/IJMS-V2I6P101
Abstract:
Background: Prostatic enlargement can be due to tumor or other causes in old age which causes significant morbidity and mortality. Prostatic cancer and benign prostatic hyperplasia are two common entities which affects the prostate. Prostate cancer is increasing in its frequency day by day. Aim: To correlate the values of PSA (total and free) and free PSA/total PSA ratio, and acid phosphatase (total and tartrate labile) with histopathological findings. Material and Methods: The study was conducted in 100 patients in the age group 50-80 years. Serum acid phosphatase (total & tartrate labile) and serum PSA (total and free) estimations were done in all cases with appropriate controls (10 age matched controls were selected for serum studies). TURP chips from patients were sent to the department of Pathology for histopathological examination and correlated with serum acid phosphatase and PSA levels. Results: Serum acid phosphatase levels (total and tartrate labile) in patients with BPH and prostatic carcinoma were found to be 8.218±2.75U/L, 1.47±0.35U/L and 17.386±5.28U/L, 14.048±4.92U/L respectively. The total PSA, free PSA and free/total PSA ratio in patients with BPH and prostatic carcinoma were found to be 9.62±2.47ng/ml, 2.91±0.63ng/ml, 0.304±0.032 and 22.42±12.37ng/ml, 1.59±0.83ng/ml, 0.072±0.01 respectively. In histopathology, 75 cases were diagnosed as BPH and 25 as prostatic carcinoma. Conclusion: Free PSA/ total PSA ratio is a better marker of prostatic carcinoma than total PSA and acid phosphatase levels and thus this investigation can prevent unnecessary invasive prostatic biopsies to a great extent
Keywords:
Benign prostatic hyperplasia, prostatic carcinoma, prostate specific antigen, acid phosphatase
References:
Benign prostatic hyperplasia, prostatic carcinoma, prostate specific antigen, acid phosphatase