Analytical Study of Thrombocytopenia in Pregnant Women in Tishreen University Hospital (Causes, Complications, Management)

International Journal of Medical Science

© 2022 by SSRG - IJMS Journal

Volume 9 Issue 1

Year of Publication : 2022

Authors : Alaa Marouf, Firas Hussein, Louai Hasan

10.14445/23939117/IJMS-V9I1P102

How to Cite?

Alaa Marouf, Firas Hussein, Louai Hasan, "Analytical Study of Thrombocytopenia in Pregnant Women in Tishreen University Hospital (Causes, Complications, Management)," SSRG International Journal of Medical Science, vol. 9,  no. 1, pp. 9-13, 2022. Crossref, https://doi.org/10.14445/23939117/IJMS-V9I1P102

Abstract:

The aims of this study are to determine the prevalence of thrombocytopenia during pregnancy, in addition to evaluating the etiologies and the outcomes of thrombocytopenia.
A prospective cohort study was conducted on 894 pregnant women. They are selected from the Department of Obstetrics and Gynecology, Tishreen University Hospital in Lattakia-Syria, between November 2020 and November 2021. Blood samples were taken, and a complete blood count CBC was performed to detect the presence of thrombocytopenia.
Results of the 894 women enrolled in the study, 75(8.4%) had thrombocytopenia. Benign gestational thrombocytopenia represented the most frequent cause of thrombocytopenia (80%), followed by immune thrombocytopenia (10.7%) and pre-eclampsia (4%). Other causes were rare, which consisted of disseminated intravascular coagulation (2.7%), Antiphospholipid syndrome (1.3%), and multiple myeloma (1.3%). The most frequent complications of thrombocytopenia were antepartum hemorrhage (8%), premature delivery (8%), and the rate of complications was the least in women with benign gestational thrombocytopenia than other etiologies. A cut of 80.000 of platelets yielded a sensitivity of 90% and specificity of 87.3% in predicting the final outcome, in which the rate of complications was higher in women with platelet count <80.000.

Keywords:

Thrombocytopenia, Pregnancy, Prevalence, Complications.

References:

[1] Reese,J;Peck,J;Deschamps,D., Platelet Counts During Pregnancy. N Engl J Med, 379(32) (2018).
[2] Kadir, R; Mclintock, C.,Thrombocytopenia and Disorders of Platelet Function in Pregnancy. Semin Thromb Hemost, 37 (2011) 640-52.
[3] Cines, D; Levine, L., Thrombocytopenia in Pregnancy, (2017). Blood.130:2271-2277.
[4] Fogerty, A (2018). Thrombocytopenia in Pregnancy: Mechanisms and Management. Transfusion Medicine Reviews,32 (2018) 225-229.
[5] Ciobanu,A;Colibaba,S;Peltecu,G., Thrombocytopenia in Pregnancy.Maedica.11 (2016) 55-60.
[6] Bockenstedt, P., Thrombocytopenia in Pregnancy. Hematol Oncol Clin North Am, 25 (2011) 293-310.
[7] Wang, X; Xu, Y; Luo, W., Thrombocytopenia in Pregnancy with Different Diagnoses: Differential Clinical Features, Treatments, and Outcomes.Med, 96 (2017) 7561.
[8] Myers, B(2012). Diagnosis and Management of Maternal Thrombocytopenia in Pregnancy. Br J Haematol, 158 (2012) 3.
[9] Myers, B., Review Thrombocytopenia In Pregnancy.Obstet Gynaecol, 11 (2009) 177-183.
[10] Gernsheimer,T;James,A;Stasi,R., How I Treat Thrombocytopenia In Pregnancy. Blood, 121 (2013) 38-47.
[11] Boehlen,R;Hohlfeld,P;Thomas,V., Platelet Count at Term Pregnancy: A Reappraisal of The Threshold. Obstetrics&Gynecology, 95 (2000) 29-33.
[12] Wang,X;Xu,Y;Feng,H.,Thrombocytopenia in Pregnancy with a Different Diagnosis.Medicine, (2017) 96:29(E7561).
[13] Khadra, M; Al-Husban, N; Fram, K., Thrombocytopenia in Pregnancy; Prevalence, Causes and Fetomaternal Outcome, 1(21) (2020)
[14] Gerbasi FR, Bottoms S, Farag A, Mammen E. Increased Intravascular Coagulation Associated with Pregnancy. Obstet Gynecol 75 (1990) 385–9.
[15] Verdy E., Bessous V., Dreyfus M., Kaplan C., Tchernia G., Uzan S.: Longitudinal Analysis of Platelet Count and Volume in Normal Pregnancy,Thromb. Haemost., 77 (1997) 806.
[16] Parnas M., Sheiner E., Shoham-Vardi I., Burstein E., Yermiahu T., Levi I., Et Al., Moderate to Severe Thrombocytopeniai Pregnancy, Eur. J. Obstet. Gynecol.Reprod. Biol., 128(163) (2006) .
[17] Tygart SG, Mcroyan DK, Spinnato JA, Mcroyan CJ, Kitay DZ. A Longitudinal Study of Platelets Indices During Normal Pregnancy. Am J Obstet Gynecol , 154 (1986) 883–7.
[18] Ahmed Y, Van Iddeking B, Paul C, Sullivan MHF, Elder MG. Retrospective Analysis of Platelet Number and Volumes in Normal Pregnancy And In Pre-Eclampsia. Br J Obstet Gynaecol, 100 (1993) 216–20.
[19] Giles C. The Platelet Counts And Means Platelet Volume. Br J Haematol, 48 (1981) 31–7.
[20] Burrows RF, Kelton JG. Incidentally Detected Thrombocytopenia In Healthy Mothers And Their Infants. N Engl J Med, 319 (1988) 142–5.
[21] Sill PR, Lind T, Walker W. Platelet Values During Normal Pregnancy. Br J Obstet Gynaecol , 92 (1985) 480-3.
[22] Rinder HM, Bonan JL, Anandan S, Rinder CS, Rodrigues PA, Smith BR. Noninvasive Measurement of Platelet Kinetics in Normal And Hypertensive Pregnancies. Am J Obstet Gynecol, 170 (1994) 117–22.
[23] Lurie S. Changes In Platelet Volume and Count During Pregnancy: A Longitudinal Study. Gynecol Obstet Invest, 40 (1995) 71–2.
[24] Burrows RF, Kelton JG. Fetal Thrombocytopenia and its Relation to Maternal Thrombocytopenia. N Engl J Med , 329 (1993) 1463– 6.
[25] Boehlen F, Hohlfeld P, Extermann P, De Moerloose P. Maternal Antiplatelet Antibodies in Predicting the Risk of Neonatal Thrombocytopenia.Obstet Gynecol, 93 (1999) 169–73.