Assessment of Prognostic Factors in Perforated Peptic Ulcers Patients

International Journal of Medical Science

© 2023 by SSRG - IJMS Journal

Volume 10 Issue 1

Year of Publication : 2023

Authors : Habib Wakkaf, Aktham Kanjarawy

10.14445/23939117/IJMS-V10I1P106

How to Cite?

Habib Wakkaf, Aktham Kanjarawy, "Assessment of Prognostic Factors in Perforated Peptic Ulcers Patients," SSRG International Journal of Medical Science, vol. 10,  no. 1, pp. 31-37, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I1P106

Abstract:

Perforated peptic ulcer is a life-threatening condition requiring emergency intervention due to high morbidity and mortality. Aim: The aim of this study is to evaluate the prognostic factors associated with outcomes of perforated ulcers. Materials and Methods: An observational prospective analytic study was conducted in adult patients diagnosed with perforated peptic ulcers who underwent modified Graham patch repair. They were selected from the General Surgery department at Tishreen University Hospital. Sociodemographic variables, with morbidity and mortality and their associated factors, were analyzed. Results: A total of 40 patients, 31 males (77.5%) and 9 females (22.5%), were included in the study. They had a mean age of 51.67±13.8 years, 20% had the concomitant disease, and 57.5% of the patients presented within 6- 24 hours. Complications occurred in 15 patients (37.5%), and mortality in 6 cases (15%). Pre-operative duration (OR 3.4), age older than 65 years (OR 3.2), comorbidities (OR 3.4), size of perforation (OR 2.9), and use of NSAIDs (OR 3.1) were independent factors that were associated with the risk of progression of complications. Pre-operative duration (OR 2.9), age older than 65 years (OR 3.6), comorbidities (OR 3.02), and size of perforation (OR 3.2) were factors that were associated independently with the risk of mortality. Conclusion: Early detection of perforation and urgent intervention are considered crucial, and the presence of older patients, delayed surgical intervention, comorbidities, and large perforations are all warning flags that may predispose to poor prognosis.

Keywords:

Morbidity, Mortality, Peptic ulcer, Perforated, Risk factors.

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