Prognostic Value of Hypoalbuminemia on Admission in Patients with COVID-19 at Tishreen University Hospital
| International Journal of Medical Science |
| © 2023 by SSRG - IJMS Journal |
| Volume 10 Issue 4 |
| Year of Publication : 2023 |
| Authors : Rawan Ibrahim, Mohammad Alkhayer, Faisal Redwan |
10.14445/23939117/IJMS-V10I4P103
How to Cite?
Rawan Ibrahim, Mohammad Alkhayer, Faisal Redwan, "Prognostic Value of Hypoalbuminemia on Admission in Patients with COVID-19 at Tishreen University Hospital," SSRG International Journal of Medical Science, vol. 10, no. 4, pp. 13-19, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I4P103
Abstract:
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has triggered a global health crisis that has affected populations and spread worldwide. It is unclear whether the outcome is modulated by serum albumin levels, in which hypoalbuminemia is associated with adverse outcomes. This study aims to investigate the association between albumin levels on admission and the outcomes of COVID-19 patients. Methods: An Analytic Cohort Study (Prospective) was conducted on patients with a proven diagnosis of COVID-19. They were selected from Pulmonology Department, Tishreen University Hospital in Lattakia-Syria between September 2021 and September 2022. The study population was divided into two groups according to the albumin levels on admission; Group I included patients with hypoalbuminemia (albumin<3.5 g/dl), and Group II included patients with normal albumin. The final outcome was compared between the two groups. Results: The population of 208 patients was predominantly male (60.1%), with a mean age of 62.1±13.5 years. 31.7% of the patients were smokers, and hypertension represented the most frequent comorbidity (41.3%). Mean values of WBC, PCT, D-Dimer, and CRP were significantly higher in patients with hypoalbuminemia (p<0.05). Low level of albumin was associated with an independent risk for mortality (RR: 4.9[2.8-9.9], p:0.0001), need for invasive ventilation (RR: 3.9[1.1-7.3], p:0.0001), need for non-invasive ventilation (RR: 4.3[1.5-11.3], p:0.0001), and admission in intensive care unit (RR: 3.8[2.2-10.5], p:0.0001). The cut-off point for mortality was albumin=3.19 g/dl, with a sensitivity of 71.3% and 63.1% specificity. Conclusion: This study demonstrated unfavorable hypoalbuminemia results on the final outcomes regarding morbidity and mortality in COVID-19 patients.
Keywords:
COVID-19, Hypoalbuminemia, ICU, Albumin, Mortality.
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