Prevalence of Primary Hypothyroidism in Patients with Non-Alcoholic Fatty Liver Disease
| International Journal of Medical Science |
| © 2023 by SSRG - IJMS Journal |
| Volume 10 Issue 5 |
| Year of Publication : 2023 |
| Authors : Dina Aljundi, Ruba Salman, Daad Daghman |
10.14445/23939117/IJMS-V10I5P103
How to Cite?
Dina Aljundi, Ruba Salman, Daad Daghman, "Prevalence of Primary Hypothyroidism in Patients with Non-Alcoholic Fatty Liver Disease," SSRG International Journal of Medical Science, vol. 10, no. 5, pp. 12-18, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I5P103
Abstract:
Introduction: There is a possible relationship between NAFLD and hypothyroidism. One suggested mechanism to explain this relationship is the well-known association between hypothyroidism and various metabolic syndrome components often present in the context of NAFLD. Objective: This study aims to estimate the prevalence of hypothyroidism in patients with non-alcoholic fatty liver disease. Methods: A case-control study of 128 patients diagnosed with NAFLD by ultrasonographic findings without a history of thyroid disorders participated in this study, who attended Tishreen University Hospital in Lattakia, Syria, during the period from May 2022 to July 2023, 128 age and gendermatched control subjects with normal liver on ultrasound, to compare the prevalence of primary hypothyroidism between the two groups. Results: Primary hypothyroidism was more prevalent among NAFLD patients by 19.5% compared to 8.5% in the controls, with a statistically significant difference (P-value: 0.001). The mean TSH value was higher in the NAFLD group compared to the controls (3.9 mui/l compared to 2.4 mui/l in the controls) with a statistically significant difference (P-value: 0.04); as for the average value of FT4, it was lower in the NAFLD group compared to the controls (1.10 ng/dl compared to 1.22 in the controls) with a significant statistical difference (P-value: 0.01). Conclusions: A higher prevalence of primary hypothyroidism was demonstrated in the NAFLD group, with both clinical and subclinical types, and this may indicate a relationship between hypothyroidism and NAFLD.
Keywords:
Insulin resistance, Metabolic syndrome, Non-alcoholic fatty liver disease, Primary hypothyroidism, Steatosis.
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