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Resistance Phenotype and Epidemiological Profile of Enterobacteriaceae Responsible for Urinary Tract Infections at the National Reference University Hospital Center in N'Djamena, Chad

International Journal of Medical Science
© 2023 by SSRG - IJMS Journal
Volume 10 Issue 5
Year of Publication : 2023
Authors : Bessimbaye Nadlaou, Mbaïressem Tamsengar Olivier, Abdelsalam Tidjani, Rimtebaye Kimassoum
10.14445/23939117/IJMS-V10I5P108
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Bessimbaye Nadlaou, Mbaïressem Tamsengar Olivier, Abdelsalam Tidjani, Rimtebaye Kimassoum, "Resistance Phenotype and Epidemiological Profile of Enterobacteriaceae Responsible for Urinary Tract Infections at the National Reference University Hospital Center in N'Djamena, Chad," SSRG International Journal of Medical Science, vol. 10,  no. 5, pp. 51-59, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I5P108

Abstract:

The geographical spread of highly resistant bacteria is a global public health problem. The aim of this study was to determine the resistance phenotypes and the epidemiological profile of Enterobacteriaceae responsible for urinary tract infections at the National Reference University Hospital Center (CHU-RN) in N'Djamena.

         This was a one-year cross-sectional study running from October 2021 to October 2022. Standard bacteriological techniques identified Enterobacteriaceae. The diffusion technique of antibiotic disks in agar medium was used to identify highly resistant Enterobacteriaceae, and that of double disk made it possible to detect Enterobacteriaceae producing ESBL. The data was collected via a face-to-face verbal interview with the patients based on the questionnaires on a survey sheet. Chi-square tests were calculated to compare qualitative variables, and a value of p < 0.05 was considered statistically significant.

         Of the 357 patients surveyed, we determined a prevalence rate of Enterobacteriaceae urinary tract infections of 72.55%. Significant differences were observed between the proportions of men and women surveyed and urinary infection of male and female genders with probabilities of 0.001 and 0.02, respectively. The most frequently identified

         Enterobacteriaceae were Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis, with proportions of 76.45%, 12.74% and 5.79% respectively. The resistance phenotypes detected were ESBL, XDR, MDR and PDR, with proportions of 58.42%, 23.59%, 15.73% and 2.24%, respectively. This study made it possible to determine high rates of resistance phenotypes of Enterobacteriaceae responsible for urinary tract infections in the departments of the CHU-RN. The results of this study raise the need for the application of recommendations for the proper use of antibiotics and to establish treatment guided by laboratory results.

Keywords:

Enterobacteriaceae, Urinary tract infection, Resistance phenotypes, Epidemiological profile, Antibiotic, Chad.

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