The Risk Factors for the Occurrence of Late-Onset Sepsis among the Admitted Patients in Neonatal Intensive Care unit at Tishreen University Hospital

International Journal of Medical Science

© 2023 by SSRG - IJMS Journal

Volume 10 Issue 6

Year of Publication : 2023

Authors : Areej Mohammad, Oday Jouni

10.14445/23939117/IJMS-V10I6P110

How to Cite?

Areej Mohammad, Oday Jouni, "The Risk Factors for the Occurrence of Late-Onset Sepsis among the Admitted Patients in Neonatal Intensive Care unit at Tishreen University Hospital," SSRG International Journal of Medical Science, vol. 10,  no. 6, pp. 62-66, 2023. Crossref, https://doi.org/10.14445/23939117/IJMS-V10I6P110

Abstract:

Background: Late-onset sepsis remains a common complication in neonates admitted to the Neonatal Intensive Care Unit (NICU) with poor outcomes, especially in critical cases. Objective: This study aimed to evaluate the risk factors associated with the occurrence of late-onset sepsis in neonates. Materials and Methods: An analytic prospective cohort study was conducted for the period of one year (2022 – 2023) at Tishreen University Hospital in Lattakia-Syria. The study included two groups of neonates that were compared: group I consisted of 76 neonates with a diagnosis of late-onset sepsis, whereas Group II consisted of 115 neonates without sepsis. Results: The results showed that 39.8% of the study population had lateonset sepsis, which was observed at 4-22 days of life. The prevalence of sepsis was increased significantly with decreasing gestational age (p:0.03), very low birth weight (p:0.001), use of vein catheters (p:0.003), administration of intravenous antibiotic(p:0.0001), parenteral nutrition (p:0.0001), and mechanical ventilation(p:0.0001). Very low birth weight (RR 5.5), use of mechanical ventilation (RR 8.4), intravenous antibiotic (RR 5.9), total parenteral nutrition (RR 6.1), and use of vein catheters (RR 5.8) were factors that associated significantly with the risk of progression late-onset sepsis. The rate of mortality was significantly higher in the presence of sepsis (11.8% versus 0.9%, p<0.05). Conclusion: There is an important prevalence of late-onset septicemia in our health center, which was associated with significant mortality. The presence of extremely low birth weight, mechanical ventilation, intravenous antibiotics, parenteral nutrition, and vein catheters are all warning flags that may predispose to septicemia after 72 hours of neonate life.

Keywords:

Late-onset sepsis, Very low birth weight, Risk factors, Nosocomial infection.

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