Pattern Electroretinography in Unilateral Non-Glaucomatous Pseudoexfoliation Patients

International Journal of Medical Science

© 2024 by SSRG - IJMS Journal

Volume 11 Issue 3

Year of Publication : 2024

Authors : Sinan Bilal, Yusuf Suleiman, Habib Yousef

10.14445/23939117/IJMS-V11I3P109

How to Cite?

Sinan Bilal, Yusuf Suleiman, Habib Yousef, "Pattern Electroretinography in Unilateral Non-Glaucomatous Pseudoexfoliation Patients," SSRG International Journal of Medical Science, vol. 11,  no. 3, pp. 59-62, 2024. Crossref, https://doi.org/10.14445/23939117/IJMS-V11I3P109

Abstract:

Aims: To study the effect of pseudoexfoliation on electrophysiological responses of the retina in the absence of glaucoma. Methods and Material: 20 patients with exfoliations apparent in one eye only and no glaucomatous optic disc and\or visual field changes were studied using pattern electroretinography. The two eyes were examined simultaneously. P50 amplitude and peak time, N95 amplitude and peak time, and P50-N95 amplitude were compared in both eyes. Results: mean P50 amplitude and time were 1.38 µV and 57.39 ms in PXS eyes and 1.50 µV and 58.08 ms in fellow eyes, respectively (p 0.620, 0.409). Mean N95 amplitude and time were -1.68 µV and 103.11 ms in PXS eyes and -1.95 µV and 106.47 ms in fellow eyes, respectively (p 0.429, 0.219). While P50-N95 amplitude was 3.06 µV in PXS eyes and 3.45 µV in fellow eyes (p 0.04). Conclusion: Pattern ERG P50 – N95 amplitude was lower in the non-glaucomatous eye with pseudoexfoliation compared to the fellow eye, so pseudoexfoliation –even without glaucoma- can affect retinal ganglion cells response, which may be considered an early sign of a possible ganglion cells injury and eventually glaucoma.

Keywords:

Pseudoexfoliation, Pattern ERG, Glaucoma, Visual field, Ganglion cells.

References:

[1] S. Tuteja, M. Zeppieri, and H. Chawla, “Pseudoexfoliation Syndrome and Glaucoma,” 2021.
[Google Scholar] [Publisher Link]
[2] Pasquale Plateroti et al., “Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma: A Review of the Literature with Updates on Surgical Management,” Journal of Ophthalmology, 2015.
[CrossRef] [Google Scholar] [Publisher Link]
[3] M, Roth, and D.L. Epstein, “Exfoliation Syndrome,” American Journal of Ophthalmology, vol. 89, no. 4, pp. 477-481, 1980.
[CrossRef] [Google Scholar] [Publisher Link]
[4] Lisa A. Kerrigan–Baumrind et al., “Number of Ganglion Cells in Glaucoma Eyes Compared with Threshold Visual Field Tests in the Same Persons,” Investigative Ophthalmology & Visual Science, vol. 41, no. 3, pp. 741-748, 2000.
[Google Scholar] [Publisher Link]
[5] André Carvalho Kreuz et al., “The Role of Pattern-Reversal Electroretinography in the Diagnosis of Glaucoma,” Arquivos Brasileiros de Oftalmologia, vol. 77, no. 6, pp. 403-410, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[6] F. Grehn, and Eugen Gramer, Pex Material and Intraocular Pressure, Pathogenesis and Risk Factors of Glaucoma, pp. 185-188, 1997.
[7] Nurşen Yüksel et al., “Analysis of Retinal Nerve Fiber Layer Thickness in Patients with Pseudoexfoliation Syndrome Using Optical Coherence Tomography,” Ophthalmologica, vol. 221, no. 5, pp. 299-304, 2007.
[CrossRef] [Google Scholar] [Publisher Link]
[8] Turkey Eman et al., “Role of Pattern Electroretinogram in Ocular Hypertension and Early Glaucoma,” Journal of Glaucoma, vol. 28, no. 10, pp. 871-877, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[9] Ebrahim Jafarzadehpour et al., “Pattern Electroretinography in Glaucoma Suspects and Early Primary Open Angle Glaucoma,” Journal of Ophthalmic & Vision Research, vol. 8, no. 3, pp. 199-206, 2013.
[Google Scholar] [Publisher Link]
[10] Sebastian F.N. Bode, Thomas Jehle, and Michael Bach, “Pattern Electroretinogram in Glaucoma Suspects: New Findings from a Longitudinal Study,” Investigative Ophthalmology & Visual Science, vol. 52, no. 7, pp. 4300-4306, 2011.
[CrossRef] [Google Scholar] [Publisher Link]