Screening For Hypothyroidism in Children with Celiac Disease

International Journal of Medical Science

© 2024 by SSRG - IJMS Journal

Volume 11 Issue 5

Year of Publication : 2024

Authors : Elein Saker, Ahmad Chreitah, Youssef Zreik

10.14445/23939117/IJMS-V11I5P102

How to Cite?

Elein Saker, Ahmad Chreitah, Youssef Zreik, "Screening For Hypothyroidism in Children with Celiac Disease," SSRG International Journal of Medical Science, vol. 11,  no. 5, pp. 13-16, 2024. Crossref, https://doi.org/10.14445/23939117/IJMS-V11I5P102

Abstract:

Background: Celiac disease is one of the most prevalent autoimmune diseases affecting the digestive system, and elicited by gluten and related prolamines in genetically susceptible individuals, it is a common disease in Arab countries, CD patients are more likely to develop autoimmune diseases, especially hypothyroidism and the appearance of symptoms and signs often occurs late, which may lead to complications related to growth, puberty, mental performance, and metabolic disorders, so it is necessary to diagnose and manage early. Objective: The study aimed to assess the frequency of hypothyroidism in children diagnosed with celiac disease. Materials and Methods: An observational, descriptive, cross-sectional study was conducted over the period of three years (May 2021 - May 2024). Out of 699 patients who underwent upper gastrointestinal endoscopy for various reasons, including 56 children (32 girls and 24 boys) aged 1-16 years who were biopsy positive for celiac disease, thyroid stimulating hormone (TSH) testing was performed for all patients. Blood samples were obtained to measure free thyroxin (FT4) testing if TSH was elevated. Results: The mean TSH was 2.74±1.9 uIU/L. Nine children (16.1%) had elevated TSH levels, 7 children (12.5%) had low levels of FT4(overt hypothyroidism), and 2 children(3.6%) had normal levels of FT4(subclinical hypothyroidism). Conclusion: There is a real increase in the cases of hypothyroidism in children with celiac disease, so thyroid function in these patients must be periodically investigated.

Keywords:

Celiac disease, Free thyroxin, Hypothyroidism, Thyroid stimulating hormone.

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