Highlighting of the antimicrobial activities of extracts of Morindamorindoides, a medicinal plant used in West and Central Africa

International Journal of Medical Science

© 2016 by SSRG - IJMS Journal

Volume 3 Issue 12

Year of Publication : 2016

Authors : Jean-Luc Aboya MOROH, Calixte BAHI, Detto KARAMOKO, Yannick FLEURY, Roger LABIA, Ivan LEGUERINEL and Adama COULIBALY

10.14445/23939117/IJMS-V3I12P104

How to Cite?

Jean-Luc Aboya MOROH, Calixte BAHI, Detto KARAMOKO, Yannick FLEURY, Roger LABIA, Ivan LEGUERINEL and Adama COULIBALY, "Highlighting of the antimicrobial activities of extracts of Morindamorindoides, a medicinal plant used in West and Central Africa," SSRG International Journal of Medical Science, vol. 3,  no. 12, pp. 18-24, 2016. Crossref, https://doi.org/10.14445/23939117/IJMS-V3I12P104

Abstract:

The renewal of the anti-infective arsenal has become over the last 10 years a public health priority. To this end, an ethno-pharmacological approach has been developed. From Traditional self-medication habits, Morindamorindoides was shown to be used throughout sub-Saharan Africa for its effects against the diarrhoea, malaria, skin infections, itching and fevers. Given the breadth of its scope, this Rubiaceae was investigated for antimicrobial potencies.After harvesting and packaging of leaves, stems and roots, extractions in water, methanol, acetonitrile, acetone, ethyl acetate or chloroform were performed. The antimicrobial activities of the extracts obtained were evaluated against eleven microbial strains. Extraction of roots using acetonitrile resulted in the higher antimicrobial activity against staphylococcus aureus.The cytotoxicity test of this crude extract exhibited an IC50 of 420.32 μg/mL on Vero cell line and 388.33 μg/mL on 3T3 cell line. The kinetics of inactivation reveals a loss of cultivability of Staphylococcus aureus and Candida albicans was modeled using the weibull model. The results of future work concerning purification and characterization of compounds of this acetonitrile extract including their cytotoxic activities could inform us of fields of application of these natural substances in human medicine, veterinary and cosmetology.

Keywords:

Medicinal plant, Morindamorindoides, antimicrobial activity, cytotoxic activity.

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