Estimation of 5’ Nucleotidase and Serum Cholinesterase as Diagnostic Marker to Distinguish Between Various Liver Diseases and Non Liver Diseases

International Journal of Medical Science

© 2017 by SSRG - IJMS Journal

Volume 4 Issue 8

Year of Publication : 2017

Authors : Dr. Varsha Chowdhry and Dr. G.G. Kaushik

10.14445/23939117/IJMS-V4I8P102

How to Cite?

Dr. Varsha Chowdhry and Dr. G.G. Kaushik, "Estimation of 5’ Nucleotidase and Serum Cholinesterase as Diagnostic Marker to Distinguish Between Various Liver Diseases and Non Liver Diseases," SSRG International Journal of Medical Science, vol. 4,  no. 8, pp. 3-6, 2017. Crossref, https://doi.org/10.14445/23939117/IJMS-V4I8P102

Abstract:

 BACKGROUND: The present study was undertaken to determine the diagnostic importance of 5’nucleotidase, serum cholinesterase enzyme activity in the patients of liver diseases and also to study the levels of different enzymes like alanine transaminase, aspartate transaminase, total bilirubin, serum albumin , and alkaline phosphatise in different liver diseases(liver cirrhosis, hepatitis, liver abscess, obstructive jaundice). METHOD: The present study was conducted on 150 subjects, of either sex of various age groups. Study included liver disorder patients (75) attending Medical OPD, patients admitted in medical and surgical wards and patients coming in clinical laboratory, Biochemistry Department J.L.N. Medical College & Hospital, Ajmer. The results of patients were compared with the hundred non liver disease patients of either sex of similar age group. The indices included :- 5’nucleotidase (by colorimetric method of cambell), serum cholinesterase (by DGKC, colorimetric method) alanine transaminase, aspartate transaminase (by NADH kinetic UV method), total bilirubin (by DMSO method), serum albumin (by bromocresol geen method), and alkaline phosphatise (pnitrophenyl phosphate, kinetic method). RESULT- The mean serum 5’Nucleotidase levels, were significantly raise in liver diseases patients in comparison to non liver disease patients (p<0.001) (HS). Mean serum cholinesterase levels were low in in liver disease patients <1979 IU/l comparison to non liver disease patients. Total bilirubin level was raised in 93.7% liver disease patients, Aspartate transaminase was raised in 84.9% patients but also in non liver disease patients (81.4%). Similarly Alanine tranaminase, Total protein and serum albumin level were low in both liver disease patients and non liver disease patients Alkaline phosphatise was raised in both in liver disease and non liver disease patients, so, it was concluded in that serum cholinesterase and 5 nucleotidase are better diagnostic marker then the conventional liver function test that are are raised in other liver disease also.

Keywords:

    5’ Nucleotidase, Serum cholinesterase, Liver diseases.

References:

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