Preparation and Evaluation of Microparticles Containing Charantin by Solvent Evaporation Technique

International Journal of Pharmacy and Biomedical Engineering

© 2019 by SSRG - IJPBE Journal

Volume 6 Issue 1

Year of Publication : 2019

Authors : Nirupama K V, Adlin Jino Nesalin J, Tamizh Mani T

10.14445/23942576/IJPBE-V6I1P103

How to Cite?

Nirupama K V, Adlin Jino Nesalin J, Tamizh Mani T, "Preparation and Evaluation of Microparticles Containing Charantin by Solvent Evaporation Technique," SSRG International Journal of Pharmacy and Biomedical Engineering, vol. 6,  no. 1, pp. 24-28, 2019. Crossref, https://doi.org/10.14445/23942576/IJPBE-V6I1P103

Abstract:

The Charantin loaded microparticles were prepared by the solvent evaporation technique by using Eudragit S 100 polymer. Microparticles of different core: coat ratio were formulated and evaluated for process yield, loading efficiency, particle size, zeta potential, in vitro drug release kinetic studies, and stability studies. The microparticles were prepared to have a particle diameter ranging approximately 68-81µm and a zeta potential 85 to 101mV. There was a steady increase in the entrapment efficiency of increasing the polymer concentration in the formulations. The in vitro release for all drug-loaded batches were found to follow to first order and provided sustained release throughout 24 h. No appreciable difference was observed in the drug content of product during 90 days in which microparticles were stored at 4˚C, room temperature, and some little difference found in drug content of product during 90days in which microparticles were stored at an accelerated temperature of 40℃ ± 2℃/75% RH. According to the data obtained, these microparticles containing Charantin opens new and exciting perspectives as drug carriers for treating the Diabetes mellitus.

Keywords:

Microparticles, Eudragit S 100, Charantin, solvent evaporation method.

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