Preparation and Evaluation of Curcumin Phytosomes by Rotary Evaporation Method

International Journal of Pharmacy and Biomedical Engineering

© 2019 by SSRG - IJPBE Journal

Volume 6 Issue 1

Year of Publication : 2019

Authors : Sachin K S, Adlin Jino Nesalin J, Tamizh Mani T

10.14445/23942576/IJPBE-V6I1P104

How to Cite?

Sachin K S, Adlin Jino Nesalin J, Tamizh Mani T, "Preparation and Evaluation of Curcumin Phytosomes by Rotary Evaporation Method," SSRG International Journal of Pharmacy and Biomedical Engineering, vol. 6,  no. 1, pp. 29-34, 2019. Crossref, https://doi.org/10.14445/23942576/IJPBE-V6I1P104

Abstract:

The objective of the study was to develop a novel Phytosome formulation of curcumin by incorporation of phospholipids, for the improved permeability, solubility and better physical characteristics. The Curcumin-pyrosomes were prepared by using Rotary evaporator method and were optimized. The formations of phytosomes were analyzed for SEM, measurement of particle size & zeta potential, drug content, drug entrapment efficiency, Percentage yield,In-vitro drug release studies and also the release kinetics of curcumin phytosomes complex. The Curcumin phytosomes prepared by using Rotary evaporator method showed better practical yield, the drug content, drug entrapment efficiency, SEM, measurement of particle size & zeta potential and other In-vitro drug release studies resulted as anticipated. The Curcumin phytosomes were found to show better solubility and compatibility with the excipients. It is concluded that Curcumin phytosomes has better physical characteristics and improved permeability, solubility than that of curcumin drug to overcome the ability to cross lipid-rich biological membranes and which results in increase oral bioavailability.

Keywords:

Curcumin, Curcumin phytosome complex, Soy lecithin.

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