Hemodynamic in Human Diabetic Abdominal Aneurysmal Aorta Using Computational Fluid Dynamics
International Journal of Pharmacy and Biomedical Engineering |
© 2021 by SSRG - IJPBE Journal |
Volume 8 Issue 2 |
Year of Publication : 2021 |
Authors : Mohammed Al-Mijalli |
How to Cite?
Mohammed Al-Mijalli, "Hemodynamic in Human Diabetic Abdominal Aneurysmal Aorta Using Computational Fluid Dynamics," SSRG International Journal of Pharmacy and Biomedical Engineering, vol. 8, no. 2, pp. 1-5, 2021. Crossref, https://doi.org/10.14445/23942576/IJPBE-V8I2P101
Abstract:
This study is based on image-based CFD (Computational Fluid Dynamic) that will help in providing an enhanced understanding of the blood pressure impact on the wall of Abdominal Aneurysmal Aorta (AAA) for diabetic patients and its relationship with whole blood viscosity (WBV). This relation can provide the physician an indication about the consequences of diabetes disease on the AAA. Simulation technique was used as it is difficult to perform such studies in real patients where AAA problems have no symptoms. Thus, the arterial systems computational models are used to inspect the growth, rupture, and thrombosis of the aneurysm. Idealized 3D AAA models are created to analyse the aorta pressure in different areas. The CFD, is a software that has been used to determine the relationship between WBV and AAA wall pressure and then to compare the obtained values to blood viscosity (BV) for normal subject. The results were compared between the normal and diabetic models. The change in the pressure values is due to the change in the viscosity values. The values of the diabetic patient’s whole blood viscosity are higher compared to the normal viscosity, which in turn is recorded as increasing the pressure on AAA wall. The results show that the BV has a direct impact on the AAA wall pressure values. Therefore, the pressure on the AAA wall increases as BV value increases.
Keywords:
Abdominal aortic aneurysm, computational fluid dynamics, diabetes, rupture.
References:
[1] Zhang, M., et al., Haemodynamic effects of stent diameter and compaction ratio on flow-diversion treatment of intracranial aneurysms: a numerical study of a successful and an unsuccessful case. Journal of biomechanics, 58 (2017) 179-186.
[2] Fu, Y., et al., Numerical simulation of the effect of pulmonary vascular resistance on the hemodynamics of reoperation after failure of one and a half ventricle repair. Frontiers in physiology, 11 (2020) 207.
[3] Soudah, E., et al., CFD modelling of abdominal aortic aneurysm on hemodynamic loads using a realistic geometry with CT. Computational and Mathematical Methods in Medicine, (2013).
[4] Abassi, Z., et al., Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy. Journal of Biomedicine and Biotechnology, (2011).
[5] Boutouyrie, P., H. Beaussier, and S. Laurent, Hemodynamic and Mechanical Factors Acting on Arteries, in Arterial Disorders, Springer. (2015) 93-99.
[6] Janka, H.U., Increased cardiovascular morbidity and mortality in diabetes mellitus: identification of the high risk patient. Diabetes research and clinical practice, 30 (1996) S85-S88.
[7] Hirsch, A., American Association for Vascular Surgery/Society for Vascular Surgery; Society for Cardiovascular Angiography and Interventions; Society for Vascular Medicine and Biology; Society of Interventional Radiology; ACC/AHA Task Force on Practice Guidelines ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): Executive summary a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines. J Am Coll Cardiol, 47 (2006) 1239-1312.
[8] Golledge, J., et al., Abdominal aortic aneurysm: pathogenesis and implications for management. Arteriosclerosis, thrombosis, and vascular biology, 26(12) (2006) 2605-2613.
[9] Dhanaraj, B., et al., Prevalence and risk factors for adult pulmonary tuberculosis in a metropolitan city of South India. PloS one, 10(4) (2015) e0124260.
[10] Cogan, D.G., L. Merola, and P.R. Laibson, Blood viscosity, serum hexosamine and diabetic retinopathy. Diabetes, 10(5) (1961) 393-395.
[11] Hoi, Y., et al., Effects of arterial geometry on aneurysm growth: three-dimensional computational fluid dynamics study. Journal of neurosurgery, 101(4) (2004) 676-681.
[12] Qiao, A., et al., Numerical simulation of physiological blood flow in 2-way coronary artery bypass grafts. Journal of biological physics, 31(2) (2005) 161-182.
[13] Cho, Y.I., M.P. Mooney, and D.J. Cho, Hemorheological disorders in diabetes mellitus. Journal of diabetes science and technology, 2(6) (2008) 1130-1138.
[14] ITO, N., et al., Hypertension research: clinical and experimental: official journal of the Japanese Society of Hypertension 29 (5) 345-352, 2006-05-01. J. Am. Soc. Nephrol, 16 (2005) 1069-1075.
[15] Cruickshank, K., et al., Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation, 106(16) (2002) 2085-2090.
[16] Laurent, S., et al., Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension, 37(5) (2001) 1236-1241.
[17] Raghavan, M.L., et al., Biomechanical failure properties and microstructural content of ruptured and unruptured abdominal aortic aneurysms. Journal of biomechanics, 44(13) (2011) 2501-2507.
[18] Martufi, G. and T. Christian Gasser, The role of biomechanical modeling in the rupture risk assessment for abdominal aortic aneurysms. Journal of biomechanical engineering, 135(2) (2013).
[19] Raut, S.S., et al., The role of geometric and biomechanical factors in abdominal aortic aneurysm rupture risk assessment. Annals of biomedical engineering, 41(7) (2013) 1459-1477.
[20] Vorp, D.A., Biomechanics of abdominal aortic aneurysm. Journal of biomechanics, 40(9) (2007) 1887-1902.
[21] Lasheras, J.C., The biomechanics of arterial aneurysms. Annu. Rev. Fluid Mech., 39 (2007) 293-319.
[22] Humphrey, J. and C. Taylor, Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models. Annu. Rev. Biomed. Eng., 10 (2008) 221-246.
[23] Taylor, T.W. and T. Yamaguchi, Three-dimensional simulation of blood flow in an abdominal aortic aneurysm—steady and unsteady flow cases. Journal of biomechanical engineering, 116(1) (1994) 89-97.
[24] Finol, E.A. and C.H. Amon, Blood flow in abdominal aortic aneurysms: pulsatile flow hemodynamics. J. Biomech. Eng., 123(5) (2001) 474-484.
[25] Les, A.S., et al., Quantification of hemodynamics in abdominal aortic aneurysms during rest and exercise using magnetic resonance imaging and computational fluid dynamics. Annals of biomedical engineering, 38(4) (2010) 1288-1313.
[26] Arzani, A., et al., A longitudinal comparison of hemodynamics and intraluminal thrombus deposition in abdominal aortic aneurysms. American Journal of Physiology-Heart and Circulatory Physiology, 307(12) (2014) H1786-H1795.
[27] Zambrano, B.A., et al., Association of intraluminal thrombus, hemodynamic forces, and abdominal aortic aneurysm expansion using longitudinal CT images. Annals of biomedical engineering, 44(5) (2016) 1502-1514.