Innovations in Polymer Science for Enhanced Pharmaceutical Delivery Systems

International Journal of Polymer and Textile Engineering
© 2024 by SSRG - IJPTE Journal
Volume 11 Issue 2
Year of Publication : 2024
Authors : Kehinde Esther Ayodeji
pdf
How to Cite?

Kehinde Esther Ayodeji, "Innovations in Polymer Science for Enhanced Pharmaceutical Delivery Systems," SSRG International Journal of Polymer and Textile Engineering, vol. 11,  no. 2, pp. 1-12, 2024. Crossref, https://doi.org/10.14445/23942592/IJPTE-V11I2P101

Abstract:

This study reviews innovations in polymer science for enhanced pharmaceutical delivery systems. The study focuses on significant advancements in the synthesis and design of polymers, examining their potential to improve the effectiveness of therapeutic treatments. It also discusses future possibilities and obstacles through a thorough analysis of existing research. This analysis has demonstrated that notable advancements in the process of creating and structuring polymers have resulted in the creation of intelligent and reactive polymers. In addition, the incorporation of nanotechnology into polymeric carriers has enhanced drug solubility, enabled targeted distribution, and facilitated controlled release mechanisms. Furthermore, both passive and aggressive targeting techniques demonstrate improved therapeutic effectiveness. Moreover, sophisticated polymers show promise in surmounting physiological obstacles, including the blood-brain barrier and mucus layers. Controlled release technologies, such as pH-responsive, temperature-sensitive, and biodegradable systems, enhance medication administration. Additionally, mixed treatments and theragnostic based on polymers in new sectors show potential for personalized medicine. Therefore, it is advisable that future research should prioritize the development of multifunctional polymer systems that integrate therapeutic and diagnostic capabilities. Furthermore, it is imperative to do further research on how to overcome biological obstacles and enhance the long-term durability of polymer-drug formulations in order to advance the area.

Keywords:

Advancement, Drug Release, Nanotechnology, Medicine.

References:

[1] Kehinde Esther, and Ayodeji, “Review of the Impact of Polymers on the Pharmaceutical Industry,” International Journal of Novel Research and Development, vol. 9, no. 1, pp. 199-208, 2024.
[Publisher Link]
[2] Rahul Bijwar, and Harshal Tare, “Revolutionizing Medicine: Advances in Polymeric Drug Delivery Systems,” International Journal of Drug Delivery Technology, vol. 14, no. 1, pp. 572-580, 2024.
[CrossRef] [Publisher Link]
[3] Suruchi Yadav, “Advancements in Pharmaceutical Formulation Development and Drug Delivery Systems,” The Pharma Innovation International Journal, vol. 8, no. 1, pp. 870-874, 2019.
[CrossRef] [Publisher Link]
[4] William B. Liechty et al., “Polymers for Drug Delivery Systems,” Annual Review of Chemical and Biomolecular Engineering, vol. 1, pp. 149-173, 2010.
[CrossRef] [Google Scholar] [Publisher Link]
[5] Priyanka Ray, “Polymer Based Drug Delivery Systems-Benchtop to Bedside Transition,” Journal of Drugs Addiction and Therapeutics, vol. 2, no. 2, pp. 1-3, 2021.
[CrossRef] [Google Scholar] [Publisher Link]
[6] Avinash Kumar Seth et al., “Smart Polymer Systems: A Futuristic Approach to Enhance Therapeutic Efficacy,” Current Organic Chemistry, vol. 28, no. 15, pp. 1164-1178, 2024.
[CrossRef] [Google Scholar] [Publisher Link]
[7] Laura Jaimes-Aguirre et al., “Polymer-Based Drug Delivery Systems, Development and Pre-Clinical Status,” Current Pharmaceutical Design, vol. 22, no. 19, pp. 2886-2903, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[8] Mamta Saiyad, and Nimish Shah, “Nanopolymers in Drug Delivery System,” Materialstoday: Proceedings, vol. 67, no. 1, pp. 25-30, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[9] Caizhi Liao, Shadow Xiao, and Xia Wang, “Bench-to-Bedside: Translational Development Landscape of Biotechnology in Healthcare,” Health Sciences Review, vol. 7, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[10] Zoilo González, Ana Ferrández-Montero, and Juan Domínguez-Robles, “Recent Advances in Polymers as Matrices for Drug Delivery Applications,” Pharmaceuticals, vol. 16, no. 12, pp. 1-4, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[11] Edgar Adrian Franco Urquiza, “Advances in Additive Manufacturing of Polymer-Fused Deposition Modeling on Textiles: From 3D Printing to Innovative 4D Printing - A Review,” Polymers, vol. 16, no. 5, pp. 1-23, 2024.
[CrossRef] [Google Scholar] [Publisher Link]
[12] Shiyu Yan et al., “Shape Memory Polymer Composites: 4D Printing, Smart Structures, and Applications,” Research A Science Partner Journal, vol. 7, pp. 1-25, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[13] Muhammad Yasir Khalid et al., “Review: 4D Printing of Shape Memory Polymer Composites: A Review on Fabrication Techniques, Applications, and Future Perspectives,” Journal of Manufacturing Processes, vol. 81, pp. 759-797, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[14] Muhammad Azfar Jamal et al., “Additive Manufacturing of Continuous Fiber-Reinforced Polymer Composites via Fused Deposition Modelling: A Comprehensive Review,” Polymers, vol. 16, no. 12, pp. 1-33, 2024.
[CrossRef] [Google Scholar] [Publisher Link]
[15] Abhijeet Hiwrale et al., “Nanofibers: A Current Era in Drug Delivery System,” Heliyon, vol. 9, no. 9, pp. 1-20, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[16] Nigel Mills, Mike Jenkins, and Stephen Kukureka, “Chapter 2-Molecular Structures and Polymer Manufacture, Plastics (Fourth Edition), Microstructure and Engineering Applications, 2020.
[CrossRef] [Google Scholar] [Publisher Link]
[17] Maria Nerantzaki, Capucine Loth, and Jean-François Lutz, “Chemical Conjugation of Nucleic Acid Aptamers and Synthetic Polymers,” Polymer Chemistry, vol. 12, no. 24, pp. 3498-3509, 2021.
[CrossRef] [Google Scholar] [Publisher Link]
[18] David Fournier, Richard Hoogenboom, and Ulrich S. Schubert, “Clicking Polymers: A Straightforward Approach to Novel Macromolecular Architectures,” Chemical Society Reviews, vol. 36, pp. 1369-1380, 2007.
[CrossRef] [Google Scholar] [Publisher Link]
[19] Rong Fu, and Guo-Dong Fu, “Polymeric Nanomaterials from Combined Click Chemistry and Controlled Radical Polymerization,” Polymer Chemistry, vol. 2, pp. 465-475, 2011.
[CrossRef] [Google Scholar] [Publisher Link]
[20] Mehmet Arslan, and M. Atilla Tasdelen, “Click Chemistry in Macromolecular Design: Complex Architectures from Functional Polymers,” Chemistry Africa, vol. 2, pp. 195-214, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[21] Allison M. Pekkanen et al., “3D Printing Polymers with Supramolecular Functionality for Biological Applications,” Biomacromolecules, vol. 18, no. 9, pp. 2669-2687, 2017.
[CrossRef] [Google Scholar] [Publisher Link]
[22] Tatiya Siripongpreda et al., “Emerging 3D Printing Based on Polymers and Nanomaterial Additives: Enhancement of Properties and Potential Applications,” European Polymer Journal, vol. 184, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[23] Satyendra Kumar, and Purshotam, “Pharmaceutical Nanotechnology: Applications in Drug Delivery,” The Pharma Innovation International Journal, vol. 8, no. 4, pp. 1315-1319, 2019.
[CrossRef] [Publisher Link]
[24] Payam Abasian et al., “Polymeric Nanocarriers in Targeted Drug Delivery Systems: A Review,” Polymers for Advanced Technologies, vol. 31, no. 12, pp. 2939-2954, 2020.
[CrossRef] [Google Scholar] [Publisher Link]
[25] Apurva Srivastava et al., “Polymers in Drug Delivery,” Journal of Biosciences and Medicines, vol. 4, no. 1, pp. 69-84, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[26] Natarajan Jawahar, and S. Meyyanathan, “Polymeric Nanoparticles for Drug Delivery and Targeting: A Comprehensive Review,” International Journal of Health and Allied Sciences, vol. 1, no. 4, 2012.
[Google Scholar] [Publisher Link]
[27] Alejandro Sosnik, Angel M. Carcaboso, and Diego A. Chiappetta, “Polymeric Nanocarriers: New Endeavors for The Optimization of The Technological Aspects of Drugs,” Recent Patents on Biomedical Engineering (Discontinued), vol. 1, no. 1, pp. 43-59, 2008
[CrossRef] [Google Scholar] [Publisher Link]
[28] S. S. Feng, “Nanomedicine: Nanoparticles of Biodegradable Polymers for Cancer Diagnosis and Treatment,” Cosmos, vol. 4, no. 2, pp. 185-201, 2008.
[CrossRef] [Google Scholar] [Publisher Link]
[29] Tabatabaei Mirakabad et al., “PLGA-Based Nanoparticles as Cancer Drug Delivery Systems,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 2, pp. 517-535, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[30] Iliyas Khan et al., “PLGA Nanoparticles and Their Versatile Role in Anticancer Drug Delivery,” Critical Reviews in Therapeutic Drug Carrier Systems, vol. 33, no. 2, pp. 159-193, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[31] Fabienne Danhier et al., “PLGA-Based Nanoparticles: An Overview of Biomedical Applications,” Journal of controlled release, vol. 161, no. 2, pp. 505-522, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[32] Maisie J. Joralemon, Samantha McRae, and Todd Emrick, “Pegylated Polymers for Medicine: from Conjugation to Self-Assembled Systems,” Chemical Communications, vol. 46, no. 9, pp. 1377-1393, 2010.
[CrossRef] [Google Scholar] [Publisher Link]
[33] Emma M. Pelegri-O’Day, En-Wei Lin, and Heather D. Maynard, “Therapeutic Protein-Polymer Conjugates: Advancing Beyond PEGylation,” Journal of the American Chemical Society, vol. 136, no. 41, pp. 14323-14332, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[34] Sankha Bhattacharya, Bhuphendra G. Prajapati, and Sudarshan Singh, “A Critical Review on The Dissemination of Ph and StimuliResponsive Polymeric Nanoparticular Systems to Improve Drug Delivery in Cancer Therapy,” Critical Reviews in Oncology/Hematology, vol. 185, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[35] Emanuel Fleige, Mohiuddin A. Quadir, and Rainer Haag, “Stimuli-Responsive Polymeric Nanocarriers for the Controlled Transport of Active Compounds: Concepts and Applications,” Advanced Drug Delivery Reviews, vol. 64, no. 9, pp. 866-884, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[36] Mosa Alsehli, “Polymeric Nanocarriers as Stimuli-Responsive Systems for Targeted Tumor (Cancer) Therapy: Recent Advances in Drug Delivery,” Saudi Pharmaceutical Journal: SPJ, vol. 28, no. 3, pp. 255-265, 2020.
[CrossRef] [Google Scholar] [Publisher Link]
[37] Ali Alsuraifi et al., “Stimuli Responsive Polymeric Systems for Cancer Therapy,” Pharmaceutics, vol. 10, no. 3, pp. 1-17, 2018.
[CrossRef] [Google Scholar] [Publisher Link]
[38] Kyung T. Oh et al., “Polymeric Nanovehicles for Anticancer Drugs with Triggering Release Mechanisms. Journal of Materials Chemistry, vol. 17, no. 38, pp. 3987-4001, 2007.
[CrossRef] [Google Scholar] [Publisher Link]
[39] Miguel Pinto et al., “Brain Drug Delivery and Neurodegenerative Diseases: Polymeric Plga-Based Nanoparticles as A Forefront Platform,” Ageing Research Reviews, vol. 79, 2022.
[CrossRef] [Google Scholar] [Publisher Link]
[40] Pratik Chakraborty et al., “Polymeric Nanotherapeutics: An Emerging Therapeutic Approach for the Management of Neurodegenerative Disorders,” Journal of Drug Delivery Science and Technology, vol. 91, no. 3, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[41] Ozana Onaca-Fischer et al., “Polymeric Nanocarriers and Nanoreactors: A Survey of Possible Therapeutic Applications,” Current Pharmaceutical Design, vol. 18, no. 18, pp. 2622-2643, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[42] Brittany L. Banik, Pouria Fattahi, and Justin L. Brown, “Polymeric Nanoparticles: The Future of Nanomedicine,” Wiley Interdisciplinary Reviews, vol. 8, no. 2, pp. 271-299, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[43] Varaporn Buraphacheep Junyaprasert, and Parichart Thummarati, “Innovative Design of Targeted Nanoparticles: Polymer-Drug Conjugates for Enhanced Cancer Therapy,” Pharmaceutics, vol. 15, no. 9, pp. 1-26, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[44] Ling Ding et al., “Polymer-Based Drug Delivery Systems for Cancer Therapeutics,” Polymers, vol. 16, no. 6, pp. 1-35, 2024.
[CrossRef] [Google Scholar] [Publisher Link]
[45] Farah Al-Sahlawi et al., “Polymer-Based Nanoparticles in Targeted Cancer Therapy: A Review,” Journal of Applied Pharmaceutical Science, pp. 1-12, 2024.
[CrossRef] [Google Scholar] [Publisher Link]
[46] Zhengnan Yang, Dona Foster, and Ali Dhinojwala, “Continuous Production of Polymer Nanoparticles Using a Membrane-Based Flow Cell,” Journal of Colloid and Interface Science, vol. 501, no. 1, pp. 150-155, 2017.
[CrossRef] [Google Scholar] [Publisher Link]
[47] Oliver S. Thomas, and Wilfried Weber, “Overcoming Physiological Barriers to Nanoparticle Delivery-Are We There Yet?,” Frontiers in Bioengineering and Biotechnology, vol. 7, pp. 1-21, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[48] Courtney Lynch et al., “Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery,” Polymers, vol. 11, no. 8, pp. 1- 24, 2019.
[CrossRef] [Google Scholar] [Publisher Link]
[49] Jesse B. Wolinsky, Yolonda L. Colson, and Mark W. Grinstaff, “Local Drug Delivery Strategies for Cancer Treatment: Gels, Nanoparticles, Polymeric Films, Rods, and Wafers,” Journal of Controlled Release, vol. 159, no. 1, pp. 14-26, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[50] Fröhlich, Eleonore, and Roblegg, Eva, “Mucus as Barrier for Drug Delivery by Nanoparticles,” Journal of Nanoscience and Nanotechnology, vol. 14, no. 1, pp. 126-136, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[51] Weisen Zhang et al., “Development of Polymeric Nanoparticles for Blood-Brain Barrier Transfer-Strategies and Challenges,” Advanced Science, vol. 8, no. 10, 2021.
[CrossRef] [Google Scholar] [Publisher Link]
[52] Samuel K. Lai, Ying-Ying Wang, and Justin Hanes, “Mucus-Penetrating Nanoparticles for Drug and Gene Delivery to Mucosal Tissues,” Advanced drug Delivery Reviews, vol. 61, no. 2, pp. 158-171, 2009.
[CrossRef] [Google Scholar] [Publisher Link]
[53] S. Dünnhaupt et al., “Nano-Carrier Systems: Strategies to Overcome the Mucus Gel Barrier,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 96, pp. 447-453, 2015.
[CrossRef] [Google Scholar] [Publisher Link]
[54] Vijayakameswara Rao Neralla et al., “Recent Progress and Advances in Stimuli-Responsive Polymers for Cancer Therapy,” Frontiers in Bioengineering and Biotechnology, vol. 6, pp. 1-15, 2018.
[CrossRef] [Google Scholar] [Publisher Link]
[55] Brian T. Luk, and Liangfang Zhang, “Current Advances in Polymer-Based Nanotheranostics for Cancer Treatment and Diagnosis,” ACS Applied Materials & Interfaces, vol. 6, no. 24, pp. 21859-21873, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[56] Ortensia Ilaria Parisi et al., “Engineered Polymer-Based Nanomaterials for Diagnostic, Therapeutic and Theranostic Applications,” Mini reviews in Medicinal Chemistry, vol. 16, no. 9, 754-761, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[57] Yang Sun, Haitao Ran, Fan Liu, “Polymer-Based Materials and Their Applications in Image-Guided Cancer Therapy,” Current medicinal chemistry, vol. 29, no. 8, pp. 1352-1368, 2021.
[CrossRef] [Google Scholar] [Publisher Link]
[58] Serge Mignani et al., “Recent Therapeutic Applications of the Theranostic Principle with Dendrimers in Oncology,” Science China Material, vol. 61, pp. 1367-1386, 2018.
[CrossRef] [Google Scholar] [Publisher Link]
[59] S.M. Hosseini et al., “Theranostic Polymeric Nanoparticles as A New Approach in Cancer Therapy and Diagnosis: A Review,” Materials Today Chemistry, vol. 29, pp. 1-16, 2023.
[CrossRef] [Google Scholar] [Publisher Link]
[60] Yinan Zhong et al., “Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy,” Biomacromolecules, vol. 15, no. 6, pp. 1955-1969, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[61] Musarrat Husain Warsi et al., Drug Delivery Potential of Dendrimeric Formulation, Dendrimers in Nanomedicine, 1 St Ed., pp. 1-21, 2021.
[Google Scholar] [Publisher Link]
[62] Joseph Jagur-Grodzinski, “Polymers for Targeted And/Or Sustained Drug Delivery,” Polymers for Advanced Technologies, vol. 20, no. 7, pp. 595-606, 2009.
[CrossRef] [Google Scholar] [Publisher Link]
[63] Nazila Kamaly et al., “Targeted Polymeric Therapeutic Nanoparticles: Design, Development and Clinical Translation,” Chemical Society Reviews, vol. 41, no. 7, pp. 2971-3010, 2012.
[CrossRef] [Google Scholar] [Publisher Link]
[64] Priya Bawa et al., “Stimuli-Responsive Polymers and Their Applications in Drug Delivery,” Biomedical Materials, vol. 4, 2009.
[CrossRef] [Google Scholar] [Publisher Link]
[65] S.R Croy, and G.S Kwon, “Polymeric Micelles for Drug Delivery,” Current Pharmaceutical Design, vol. 12, no. 36, pp. 4669-4684, 2006.
[CrossRef] [Google Scholar] [Publisher Link]
[66] Jianjun Cheng, and Suzie H. Pun, “Polymeric Biomaterials for Cancer Nanotechnology,” Biomaterials Science, vol. 3, no. 7, pp. 891-893, 2015.
[CrossRef] [Google Scholar] [Publisher Link]
[67] Brian E. Grottkau et al., “Polymeric Nanoparticles for A Drug Delivery System,” Current Drug Metabolism, vol. 14, no. 8, pp. 840-846, 2013.
[CrossRef] [Google Scholar] [Publisher Link]
[68] Kore, Girish et al., “Polymeric Micelle as Multifunctional Pharmaceutical Carriers,” Journal of Nanoscience and Nanotechnology, vol. 14, no. 1, pp. 288-307, 2014.
[CrossRef] [Google Scholar] [Publisher Link]
[69] Nobuhiro Nishiyama, Yasuhiro Matsumura, and Kazunori Kataoka, “Development of Polymeric Micelles for Targeting Intractable Cancers,” Cancer Science, vol. 107, no. 7, pp. 867-874, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[70] Deepti Pandita, Sandeep Kumar, and Viney Lather, “Hybrid Poly (Lactic-Co-Glycolic Acid) Nanoparticles: Design and Delivery Prospectives,” Drug Discovery Today, vol .20, no. 1, pp. 95-104, 2015.
[CrossRef] [Google Scholar] [Publisher Link]
[71] Kamlesh Shroff, and Ajay Vidyasagar, “Polymer Nanoparticles: Newer Strategies towards Targeted Cancer Therapy,” Journal of Physical Chemistry and Biophysics, vol. 3, no. 4, pp. 1-3, 2013.
[CrossRef] [Google Scholar] [Publisher Link]
[72] Karel Ulbrich et al., “Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies,” Chemical Reviews, vol. 116, no. 9, pp. 5338-5431, 2016.
[CrossRef] [Google Scholar] [Publisher Link]
[73] Hongyan Xu et al., “Targeted Polymer-Drug Conjugates: Current Progress and Future Perspective,” Colloids and Surfaces B: Biointerfaces, vol. 136, pp. 729-734, 2015.
[CrossRef] [Google Scholar] [Publisher Link]
[74] Takayuki Yoshida et al., “pH- And Ion-Sensitive Polymers for Drug Delivery,” Expert Opinion on Drug Delivery, vol. 10, no. 11, pp. 1497-1513, 2013.
[CrossRef] [Google Scholar] [Publisher Link]