Revan Polynomials of Chloroquine, Hydroxychloroquine, Remdesivir: Research for the Treatment of COVID-19

International Journal of Applied Chemistry

© 2020 by SSRG - IJAC Journal

Volume 7 Issue 2

Year of Publication : 2020

Authors : V.R.Kulli

10.14445/23939133/IJAC-V7I2P102

How to Cite?

V.R.Kulli, "Revan Polynomials of Chloroquine, Hydroxychloroquine, Remdesivir: Research for the Treatment of COVID-19," SSRG International Journal of Applied Chemistry, vol. 7,  no. 2, pp. 6-12, 2020. Crossref, https://doi.org/10.14445/23939133/IJAC-V7I2P102

Abstract:

In Chemical Science, chemical, biological, pharmaceutical properties of molecular structure are essential for drug design. These properties can be studied by topological index calculation. In this study, we obtain some topological properties of molecular structures of chloroquine, hydroxychloroquine and remdesivir. We determine some Revan polynomials for these three chemical antiviral agents. The results obtained can be helpful in finding new drug and vaccine for the treatment of COVID-19.

Keywords:

molecular structure, Revan polynomials, antiviral agent, chloroquine, hydroxychloroquine, remdesivir.

References:

[1] C. Huang, et al., “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”, The Lancet Vol. 395, 10223, pp. 497-506 2020, doi: 10.1016/S0140-6736(20) 30183-5.
[2] E.Schrenzenmeier and T.Dorner, “Mechanisms of action of hydroxychloroquine and chloroquine implications of rheumatology”, Nat. Rev. Rheumatol, Vol. 16 (2020) 155- 166.
[3] M. Wang, et al., “Remdesivir and chloroquine effectively inhabit the recently emerged noval coronavirus (2019-nCoV) in vitro”, Cell Research, Vol. 30, pp. 269-271, 2020. doi:10.1038/s41422-020-0282-0.
[4] X. Xu, et al., “Evolution of the noval coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission”, Sci. China Life Sci. Vol. 63(3). pp. 457-460, 2020 doi:10.1007/s 11427- 020-1637-5.
[5] D. Zhou, S.M. Dai and Q. Tongg, “COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression”, J. Antimicrob. Chemother. 2020:dkaa 114, doi:10.1093/jac.dkaa114.
[6] V.R.Kulli, K Banhatti indices of chloroquine and hydroxychloroquine: Research Applied for the treatment and prevention of COVID-19, SSRG International Journal of Applied Chemistry, 7(1) (2020) 63-68.
[7] V.R.Kulli, Revan indices of chloroquine and hydroxychloroquine, remdesivir: Research advances for the treatment of COVID-19, International Journal of Engineering Sciences and Research Technology, 9(5) (2020) 73-84. Doi: 10.5281/zenodo.3828871.
[8] D.Plantone and T.Koudriavtseva, “Current and future use of chloroquine and hydroxychloroquine in infections, immune, Neoplastic and Neurological disease: A Mini-Review”, Clin Drug Investing, Vol. 38(8), pp. 653-671, 2018 doi: 10.1007/s40261-018-4056-y (PubMed:29737455).
[9] FDA: Emergency Use Authorization Information (Link).
[10] I. Gutman and O.E. Polansky, Mathematical Concepts in Organic Chemistry, Springer, Berlin 1986.
[11] I. Gutman and N. Trinajstić, “Graph theory and molecular orbitals. Total -electron energy of alternant hydrocarbons”, Chem. Phys. Lett. Vol. 17, pp 535-538, 1972.
[12] V.R.Kulli, “Revan indices of oxide and honeycomb networks”, International Journal of Mathematics and its Applications, 5(4-E) (2017) 663-667.
[13] V.R.Kulli, “Hyper Revan indices and their polynomials of silicate networks”, International Journal of Current Research in Science and Technology, 4(3) (2018) 17-21.
[14] V.R.Kulli, “Computing the F-Revan and modified Revan indices of certain nanostructures”, J. Comp. and Math. Sci. 9(10) (2018) 1326-1333.
[15] V.R.Kulli, “The sum connectivity Revan index of silicate and hexagonal networks”, Annals of Pure and Applied Mathematics, 14(3) (2017) 401-406.
[16] V.R.Kulli, “On the product connectivity Revan index of certain nanotubes”, Journal of Computer and Mathematical Sciences, 8(10) (2017) 562-567.
[17] V.R.Kulli, “F-Revan index and R-Revan polynomial of some families of Benzenoid systems”, Journal of Global Research in mathematical Archives, 5(11) (2018) 1-6.